Index: lib/Transforms/InstCombine/InstCombineCalls.cpp
===================================================================
--- lib/Transforms/InstCombine/InstCombineCalls.cpp
+++ lib/Transforms/InstCombine/InstCombineCalls.cpp
@@ -2242,11 +2242,18 @@
       return eraseInstFromFunction(CI);
     break;
   }
-  case Intrinsic::lifetime_start:
+  case Intrinsic::lifetime_start: {
+    const Function *func = II->getFunction();
+    // Asan needs to poison memory to detect invalid access which is possible
+    // even for empty lifetime range.
+    if (func && func->hasFnAttribute(Attribute::SanitizeAddress))
+      break;
+
     if (removeTriviallyEmptyRange(*II, Intrinsic::lifetime_start,
                                   Intrinsic::lifetime_end, *this))
       return nullptr;
     break;
+  }
   case Intrinsic::assume: {
     Value *IIOperand = II->getArgOperand(0);
     // Remove an assume if it is immediately followed by an identical assume.
Index: test/Transforms/InstCombine/lifetime-asan.ll
===================================================================
--- /dev/null
+++ test/Transforms/InstCombine/lifetime-asan.ll
@@ -0,0 +1,37 @@
+; RUN: opt < %s -instcombine -S | FileCheck %s
+
+declare void @llvm.lifetime.start(i64, i8* nocapture)
+declare void @llvm.lifetime.end(i64, i8* nocapture)
+declare void @foo(i8* nocapture)
+
+define void @asan() sanitize_address {
+entry:
+  ; CHECK-LABEL: @asan(
+  %text = alloca [1 x i8], align 1
+  %0 = getelementptr inbounds [1 x i8], [1 x i8]* %text, i64 0, i64 0
+
+  call void @llvm.lifetime.start(i64 1, i8* %0)
+  call void @llvm.lifetime.end(i64 1, i8* %0)
+  ; CHECK: call void @llvm.lifetime.start
+  ; CHECK-NEXT: call void @llvm.lifetime.end
+
+  call void @foo(i8* %0) ; Keep alloca alive
+
+  ret void
+}
+
+
+define void @no_asan() {
+entry:
+  ; CHECK-LABEL: @no_asan(
+  %text = alloca [1 x i8], align 1
+  %0 = getelementptr inbounds [1 x i8], [1 x i8]* %text, i64 0, i64 0
+
+  call void @llvm.lifetime.start(i64 1, i8* %0)
+  call void @llvm.lifetime.end(i64 1, i8* %0)
+  ; CHECK-NO: call void @llvm.lifetime
+
+  call void @foo(i8* %0) ; Keep alloca alive
+
+  ret void
+}