Index: lib/Transforms/InstCombine/InstCombineCasts.cpp
===================================================================
--- lib/Transforms/InstCombine/InstCombineCasts.cpp
+++ lib/Transforms/InstCombine/InstCombineCasts.cpp
@@ -577,8 +577,10 @@
     return I;
 
   // When trunc operand is a widened load, see if we can get the value from a
-  // previous store/load
-  if (auto *LI = dyn_cast<LoadInst>(Src)) {
+  // previous store/load. This rule works for LE layout only. For a BE layout,
+  // we would require a shr and a trunc to refer to same content that an LE
+  // memory layout refers through a trunc.
+  if (DL.isLittleEndian()  && auto *LI = dyn_cast<LoadInst>(Src)) {
     BasicBlock::iterator BBI(*LI);
 
     // Scan a few instructions up from LI and if we find a partial load/store