Index: lib/Target/AMDGPU/SIAnnotateControlFlow.cpp
===================================================================
--- lib/Target/AMDGPU/SIAnnotateControlFlow.cpp
+++ lib/Target/AMDGPU/SIAnnotateControlFlow.cpp
@@ -368,8 +368,9 @@
   }
 
   Value *Exec = popSaved();
-  if (!isa<UndefValue>(Exec))
-    CallInst::Create(EndCf, Exec, "", &*BB->getFirstInsertionPt());
+  Instruction *FirstInsertionPt = &*BB->getFirstInsertionPt();
+  if (!isa<UndefValue>(Exec) && !isa<UnreachableInst>(FirstInsertionPt))
+    CallInst::Create(EndCf, Exec, "", FirstInsertionPt);
 }
 
 /// \brief Annotate the control flow with intrinsics so the backend can
Index: test/CodeGen/AMDGPU/si-annotate-cf-unreachable.ll
===================================================================
--- /dev/null
+++ test/CodeGen/AMDGPU/si-annotate-cf-unreachable.ll
@@ -0,0 +1,40 @@
+; RUN: opt -mtriple=amdgcn-- -S -structurizecfg -si-annotate-control-flow %s | FileCheck -check-prefix=OPT %s
+; RUN: llc -march=amdgcn -verify-machineinstrs < %s | FileCheck -check-prefix=GCN %s
+
+
+; OPT-LABEL: @annotate_unreachable(
+; OPT: call { i1, i64 } @llvm.amdgcn.if(
+; OPT-NOT: call void @llvm.amdgcn.end.cf(
+
+
+; GCN-LABEL: {{^}}annotate_unreachable:
+; GCN: s_and_saveexec_b64
+; GCN-NOT: s_endpgm
+; GCN: .Lfunc_end0
+define void @annotate_unreachable(<4 x float> addrspace(1)* noalias nocapture readonly %arg) #0 {
+bb:
+  %tmp = tail call i32 @llvm.amdgcn.workitem.id.x()
+  br label %bb1
+
+bb1:                                              ; preds = %bb
+  %tmp2 = sext i32 %tmp to i64
+  %tmp3 = getelementptr inbounds <4 x float>, <4 x float> addrspace(1)* %arg, i64 %tmp2
+  %tmp4 = load <4 x float>, <4 x float> addrspace(1)* %tmp3, align 16
+  br i1 undef, label %bb3, label %bb5  ; label order reversed
+
+bb3:                                              ; preds = %bb1
+  %tmp6 = extractelement <4 x float> %tmp4, i32 2
+  %tmp7 = fcmp olt float %tmp6, 0.000000e+00
+  br i1 %tmp7, label %bb4, label %bb5
+
+bb4:                                              ; preds = %bb3
+  unreachable
+
+bb5:                                              ; preds = %bb3, %bb1
+  unreachable
+}
+
+declare i32 @llvm.amdgcn.workitem.id.x() #1
+
+attributes #0 = { nounwind }
+attributes #1 = { nounwind readnone }