Index: lib/Transforms/Vectorize/LoadStoreVectorizer.cpp
===================================================================
--- lib/Transforms/Vectorize/LoadStoreVectorizer.cpp
+++ lib/Transforms/Vectorize/LoadStoreVectorizer.cpp
@@ -424,15 +424,11 @@
 
       Instruction *M0 = cast<Instruction>(V);
       Instruction *M1 = cast<Instruction>(VV);
-      Value *Ptr0 = isa<LoadInst>(M0) ? M0->getOperand(0) : M0->getOperand(1);
-      Value *Ptr1 = isa<LoadInst>(M1) ? M1->getOperand(0) : M1->getOperand(1);
-      unsigned S0 =
-        DL.getTypeStoreSize(Ptr0->getType()->getPointerElementType());
-      unsigned S1 =
-        DL.getTypeStoreSize(Ptr1->getType()->getPointerElementType());
-
-      if (AA.alias(MemoryLocation(Ptr0, S0), MemoryLocation(Ptr1, S1))) {
+
+      if (!AA.isNoAlias(MemoryLocation::get(M0), MemoryLocation::get(M1))) {
         DEBUG(
+          Value *Ptr0 = isa<LoadInst>(M0) ? M0->getOperand(0) : M0->getOperand(1);
+          Value *Ptr1 = isa<LoadInst>(M1) ? M1->getOperand(0) : M1->getOperand(1);
           dbgs() << "LSV: Found alias.\n"
                     "        Aliasing instruction and pointer:\n"
             << *V << " aliases " << *Ptr0 << '\n'
Index: test/Transforms/LoadStoreVectorizer/AMDGPU/aa-metadata.ll
===================================================================
--- /dev/null
+++ test/Transforms/LoadStoreVectorizer/AMDGPU/aa-metadata.ll
@@ -0,0 +1,32 @@
+; RUN: opt -mtriple=amdgcn-amd-amdhsa -basicaa -scoped-noalias -load-store-vectorizer -S -o - %s | FileCheck -check-prefix=SCOPE -check-prefix=ALL %s
+; RUN: opt -mtriple=amdgcn-amd-amdhsa -basicaa -load-store-vectorizer -S -o - %s | FileCheck -check-prefix=NOSCOPE -check-prefix=ALL %s
+
+target datalayout = "e-p:32:32-p1:64:64-p2:64:64-p3:32:32-p4:64:64-p5:32:32-p24:64:64-i64:64-v16:16-v24:32-v32:32-v48:64-v96:128-v192:256-v256:256-v512:512-v1024:1024-v2048:2048-n32:64"
+
+; This fails to vectorize if the !alias.scope is not used
+
+; ALL-LABEL: @vectorize_alias_scope(
+; SCOPE: load float, float addrspace(1)* %c
+; SCOPE: bitcast float addrspace(1)* %a to <2 x float> addrspace(1)*
+; SCOPE: store <2 x float> zeroinitializer
+; SCOPE: store float %ld.c, float addrspace(1)* %b,
+
+; NOSCOPE: store float
+; NOSCOPE: load float
+; NOSCOPE: store float
+; NOSCOPE: store float
+define void @vectorize_alias_scope(float addrspace(1)* nocapture %a, float addrspace(1)* nocapture %b, float addrspace(1)* nocapture readonly %c) #0 {
+entry:
+  %a.idx.1 = getelementptr inbounds float, float addrspace(1)* %a, i64 1
+  store float 0.0, float addrspace(1)* %a, align 4, !noalias !0
+  %ld.c = load float, float addrspace(1)* %c, align 4, !alias.scope !0
+  store float 0.0, float addrspace(1)* %a.idx.1, align 4, !noalias !0
+  store float %ld.c, float addrspace(1)* %b, align 4, !noalias !0
+  ret void
+}
+
+attributes #0 = { nounwind }
+
+!0 = !{!1}
+!1 = distinct !{!1, !2, !"some scope"}
+!2 = distinct !{!2, !"some domain"}