diff --git a/llvm/lib/CodeGen/ExpandVectorPredication.cpp b/llvm/lib/CodeGen/ExpandVectorPredication.cpp
--- a/llvm/lib/CodeGen/ExpandVectorPredication.cpp
+++ b/llvm/lib/CodeGen/ExpandVectorPredication.cpp
@@ -179,6 +179,10 @@
   Value *expandPredicationInReduction(IRBuilder<> &Builder,
                                       VPReductionIntrinsic &PI);
 
+  /// Lower this VP cast operation to a non-VP intrinsic.
+  Value *expandPredicationToCastIntrinsic(IRBuilder<> &Builder,
+                                          VPIntrinsic &VPI);
+
   /// Lower this VP memory operation to a non-VP intrinsic.
   Value *expandPredicationInMemoryIntrinsic(IRBuilder<> &Builder,
                                             VPIntrinsic &VPI);
@@ -436,6 +440,27 @@
   return Reduction;
 }
 
+Value *CachingVPExpander::expandPredicationToCastIntrinsic(IRBuilder<> &Builder,
+                                                           VPIntrinsic &VPI) {
+  // TODO: Add anthor Cast Intrinsic, VP_TRUNC/VP_ZEXT
+  switch (VPI.getIntrinsicID()) {
+  default:
+    llvm_unreachable("Not a VP memory intrinsic");
+  case Intrinsic::vp_inttoptr: {
+    Value *NewOp =
+        Builder.CreateIntToPtr(VPI.getOperand(0), VPI.getType(), VPI.getName());
+    replaceOperation(*NewOp, VPI);
+    return NewOp;
+  }
+  case Intrinsic::vp_ptrtoint: {
+    Value *NewOp =
+        Builder.CreatePtrToInt(VPI.getOperand(0), VPI.getType(), VPI.getName());
+    replaceOperation(*NewOp, VPI);
+    return NewOp;
+  }
+  }
+}
+
 Value *
 CachingVPExpander::expandPredicationInMemoryIntrinsic(IRBuilder<> &Builder,
                                                       VPIntrinsic &VPI) {
@@ -598,6 +623,10 @@
   if (auto *VPCmp = dyn_cast<VPCmpIntrinsic>(&VPI))
     return expandPredicationInComparison(Builder, *VPCmp);
 
+  if (VPCastIntrinsic::isVPCast(VPI.getIntrinsicID())) {
+    return expandPredicationToCastIntrinsic(Builder, VPI);
+  }
+
   switch (VPI.getIntrinsicID()) {
   default:
     break;
diff --git a/llvm/test/CodeGen/X86/expand-vp-cast-intrinsics.ll b/llvm/test/CodeGen/X86/expand-vp-cast-intrinsics.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/CodeGen/X86/expand-vp-cast-intrinsics.ll
@@ -0,0 +1,119 @@
+; NOTE: Assertions have been autogenerated by utils/update_llc_test_checks.py UTC_ARGS: --version 3
+; RUN: llc < %s -mtriple=i686-unknown-unknown -mattr=+avx        | FileCheck %s --check-prefixes=X86
+; RUN: llc < %s -mtriple=x86_64-unknown-unknown                  | FileCheck %s --check-prefixes=SSE
+; RUN: llc < %s -mtriple=x86_64-unknown-unknown -mattr=+avx      | FileCheck %s --check-prefixes=AVX,AVX1
+; RUN: llc < %s -mtriple=x86_64-unknown-unknown -mattr=+avx2     | FileCheck %s --check-prefixes=AVX,AVX2
+; RUN: llc < %s -mtriple=x86_64-unknown-unknown -mattr=+avx512vl | FileCheck %s --check-prefixes=AVX,AVX512
+
+declare <4 x ptr> @llvm.vp.inttoptr.v4p0.v4i32(<4 x i32>, <4 x i1>, i32)
+define <4 x ptr> @inttoptr_v4p0_v4i32(<4 x i32> %va, <4 x i1> %m, i32 zeroext %evl) {
+; X86-LABEL: inttoptr_v4p0_v4i32:
+; X86:       # %bb.0:
+; X86-NEXT:    retl
+;
+; SSE-LABEL: inttoptr_v4p0_v4i32:
+; SSE:       # %bb.0:
+; SSE-NEXT:    movaps %xmm0, %xmm1
+; SSE-NEXT:    xorps %xmm2, %xmm2
+; SSE-NEXT:    unpcklps {{.*#+}} xmm0 = xmm0[0],xmm2[0],xmm0[1],xmm2[1]
+; SSE-NEXT:    unpckhps {{.*#+}} xmm1 = xmm1[2],xmm2[2],xmm1[3],xmm2[3]
+; SSE-NEXT:    retq
+;
+; AVX1-LABEL: inttoptr_v4p0_v4i32:
+; AVX1:       # %bb.0:
+; AVX1-NEXT:    vpxor %xmm1, %xmm1, %xmm1
+; AVX1-NEXT:    vpunpckhdq {{.*#+}} xmm1 = xmm0[2],xmm1[2],xmm0[3],xmm1[3]
+; AVX1-NEXT:    vpmovzxdq {{.*#+}} xmm0 = xmm0[0],zero,xmm0[1],zero
+; AVX1-NEXT:    vinsertf128 $1, %xmm1, %ymm0, %ymm0
+; AVX1-NEXT:    retq
+;
+; AVX2-LABEL: inttoptr_v4p0_v4i32:
+; AVX2:       # %bb.0:
+; AVX2-NEXT:    vpmovzxdq {{.*#+}} ymm0 = xmm0[0],zero,xmm0[1],zero,xmm0[2],zero,xmm0[3],zero
+; AVX2-NEXT:    retq
+;
+; AVX512-LABEL: inttoptr_v4p0_v4i32:
+; AVX512:       # %bb.0:
+; AVX512-NEXT:    vpmovzxdq {{.*#+}} ymm0 = xmm0[0],zero,xmm0[1],zero,xmm0[2],zero,xmm0[3],zero
+; AVX512-NEXT:    retq
+  %v = call <4 x ptr> @llvm.vp.inttoptr.v4p0.v4i32(<4 x i32> %va, <4 x i1> %m, i32 %evl)
+  ret <4 x ptr> %v
+}
+
+declare <4 x ptr> @llvm.vp.inttoptr.v4p0.v4i64(<4 x i64>, <4 x i1>, i32)
+
+define <4 x ptr> @inttoptr_v4p0_v4i64(<4 x i64> %va, <4 x i1> %m, i32 zeroext %evl) {
+; X86-LABEL: inttoptr_v4p0_v4i64:
+; X86:       # %bb.0:
+; X86-NEXT:    vextractf128 $1, %ymm0, %xmm1
+; X86-NEXT:    vshufps {{.*#+}} xmm0 = xmm0[0,2],xmm1[0,2]
+; X86-NEXT:    vzeroupper
+; X86-NEXT:    retl
+;
+; SSE-LABEL: inttoptr_v4p0_v4i64:
+; SSE:       # %bb.0:
+; SSE-NEXT:    retq
+;
+; AVX-LABEL: inttoptr_v4p0_v4i64:
+; AVX:       # %bb.0:
+; AVX-NEXT:    retq
+  %v = call <4 x ptr> @llvm.vp.inttoptr.v4p0.v4i64(<4 x i64> %va, <4 x i1> %m, i32 %evl)
+  ret <4 x ptr> %v
+}
+
+declare <4 x i32> @llvm.vp.ptrtoint.v4i32.v4p0(<4 x ptr>, <4 x i1>, i32)
+
+define <4 x i32> @ptrtoint_v4i32_v4p0(<4 x ptr> %va, <4 x i1> %m, i32 zeroext %evl) {
+; X86-LABEL: ptrtoint_v4i32_v4p0:
+; X86:       # %bb.0:
+; X86-NEXT:    retl
+;
+; SSE-LABEL: ptrtoint_v4i32_v4p0:
+; SSE:       # %bb.0:
+; SSE-NEXT:    shufps {{.*#+}} xmm0 = xmm0[0,2],xmm1[0,2]
+; SSE-NEXT:    retq
+;
+; AVX1-LABEL: ptrtoint_v4i32_v4p0:
+; AVX1:       # %bb.0:
+; AVX1-NEXT:    vextractf128 $1, %ymm0, %xmm1
+; AVX1-NEXT:    vshufps {{.*#+}} xmm0 = xmm0[0,2],xmm1[0,2]
+; AVX1-NEXT:    vzeroupper
+; AVX1-NEXT:    retq
+;
+; AVX2-LABEL: ptrtoint_v4i32_v4p0:
+; AVX2:       # %bb.0:
+; AVX2-NEXT:    vextractf128 $1, %ymm0, %xmm1
+; AVX2-NEXT:    vshufps {{.*#+}} xmm0 = xmm0[0,2],xmm1[0,2]
+; AVX2-NEXT:    vzeroupper
+; AVX2-NEXT:    retq
+;
+; AVX512-LABEL: ptrtoint_v4i32_v4p0:
+; AVX512:       # %bb.0:
+; AVX512-NEXT:    vpmovqd %ymm0, %xmm0
+; AVX512-NEXT:    vzeroupper
+; AVX512-NEXT:    retq
+  %v = call <4 x i32> @llvm.vp.ptrtoint.v4i32.v4p0(<4 x ptr> %va, <4 x i1> %m, i32 %evl)
+  ret <4 x i32> %v
+}
+
+declare <4 x i64> @llvm.vp.ptrtoint.v4i64.v4p0(<4 x ptr>, <4 x i1>, i32)
+
+define <4 x i64> @ptrtoint_v4i64_v4p0(<4 x ptr> %va, <4 x i1> %m, i32 zeroext %evl) {
+; X86-LABEL: ptrtoint_v4i64_v4p0:
+; X86:       # %bb.0:
+; X86-NEXT:    vpxor %xmm1, %xmm1, %xmm1
+; X86-NEXT:    vpunpckhdq {{.*#+}} xmm1 = xmm0[2],xmm1[2],xmm0[3],xmm1[3]
+; X86-NEXT:    vpmovzxdq {{.*#+}} xmm0 = xmm0[0],zero,xmm0[1],zero
+; X86-NEXT:    vinsertf128 $1, %xmm1, %ymm0, %ymm0
+; X86-NEXT:    retl
+;
+; SSE-LABEL: ptrtoint_v4i64_v4p0:
+; SSE:       # %bb.0:
+; SSE-NEXT:    retq
+;
+; AVX-LABEL: ptrtoint_v4i64_v4p0:
+; AVX:       # %bb.0:
+; AVX-NEXT:    retq
+  %v = call <4 x i64> @llvm.vp.ptrtoint.v4i64.v4p0(<4 x ptr> %va, <4 x i1> %m, i32 %evl)
+  ret <4 x i64> %v
+}