diff --git a/llvm/include/llvm/IR/IntrinsicsAMDGPU.td b/llvm/include/llvm/IR/IntrinsicsAMDGPU.td
--- a/llvm/include/llvm/IR/IntrinsicsAMDGPU.td
+++ b/llvm/include/llvm/IR/IntrinsicsAMDGPU.td
@@ -1677,6 +1677,11 @@
                                 IntrHasSideEffects]> {
 }
 
+def int_amdgcn_s_nop :
+  DefaultAttrsIntrinsic<[], [llvm_i16_ty], [ImmArg<ArgIndex<0>>, IntrNoMem,
+                                IntrHasSideEffects]> {
+}
+
 def int_amdgcn_s_incperflevel :
   ClangBuiltin<"__builtin_amdgcn_s_incperflevel">,
   DefaultAttrsIntrinsic<[], [llvm_i32_ty], [ImmArg<ArgIndex<0>>, IntrNoMem,
diff --git a/llvm/lib/Target/AMDGPU/AMDGPUMCInstLower.cpp b/llvm/lib/Target/AMDGPU/AMDGPUMCInstLower.cpp
--- a/llvm/lib/Target/AMDGPU/AMDGPUMCInstLower.cpp
+++ b/llvm/lib/Target/AMDGPU/AMDGPUMCInstLower.cpp
@@ -138,6 +138,8 @@
              Opcode == AMDGPU::SI_TCRETURN_GFX) {
     // TODO: How to use branch immediate and avoid register+add?
     Opcode = AMDGPU::S_SETPC_B64;
+  } else if (Opcode == AMDGPU::S_NOP_se) {
+    Opcode = AMDGPU::S_NOP;
   }
 
   int MCOpcode = TII->pseudoToMCOpcode(Opcode);
diff --git a/llvm/lib/Target/AMDGPU/SOPInstructions.td b/llvm/lib/Target/AMDGPU/SOPInstructions.td
--- a/llvm/lib/Target/AMDGPU/SOPInstructions.td
+++ b/llvm/lib/Target/AMDGPU/SOPInstructions.td
@@ -1163,6 +1163,12 @@
 
 def S_NOP : SOPP_Pseudo<"s_nop" , (ins i16imm:$simm16), "$simm16">;
 
+// Define variant marked as having side effects for use with intrinsic
+def S_NOP_se : SOPP_Pseudo<"" , (ins i16imm:$simm16), "$simm16",
+  [(int_amdgcn_s_nop timm:$simm16)]> {
+  let hasSideEffects = 1;
+}
+
 let isTerminator = 1 in {
 def S_ENDPGM : SOPP_Pseudo<"s_endpgm", (ins Endpgm:$simm16), "$simm16", [], ""> {
   let isBarrier = 1;
diff --git a/llvm/test/CodeGen/AMDGPU/llvm.amdgcn.s.nop.ll b/llvm/test/CodeGen/AMDGPU/llvm.amdgcn.s.nop.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/CodeGen/AMDGPU/llvm.amdgcn.s.nop.ll
@@ -0,0 +1,30 @@
+; NOTE: Assertions have been autogenerated by utils/update_llc_test_checks.py
+; RUN: llc -march=amdgcn -mcpu=gfx900 -verify-machineinstrs < %s | FileCheck -check-prefix=GCN %s
+; RUN: llc -global-isel -march=amdgcn -mcpu=gfx900 -verify-machineinstrs < %s | FileCheck -check-prefix=GCN %s
+
+define amdgpu_kernel void @test_s_nop() {
+; GCN-LABEL: test_s_nop:
+; GCN:       ; %bb.0:
+; GCN-NEXT:    s_nop 0
+; GCN-NEXT:    s_nop 1
+; GCN-NEXT:    s_nop 2
+; GCN-NEXT:    s_nop 3
+; GCN-NEXT:    s_nop 4
+; GCN-NEXT:    s_nop 5
+; GCN-NEXT:    s_nop 6
+; GCN-NEXT:    s_nop 7
+; GCN-NEXT:    s_nop 63
+; GCN-NEXT:    s_endpgm
+  call void @llvm.amdgcn.s.nop(i16 0)
+  call void @llvm.amdgcn.s.nop(i16 1)
+  call void @llvm.amdgcn.s.nop(i16 2)
+  call void @llvm.amdgcn.s.nop(i16 3)
+  call void @llvm.amdgcn.s.nop(i16 4)
+  call void @llvm.amdgcn.s.nop(i16 5)
+  call void @llvm.amdgcn.s.nop(i16 6)
+  call void @llvm.amdgcn.s.nop(i16 7)
+  call void @llvm.amdgcn.s.nop(i16 63)
+  ret void
+}
+
+declare void @llvm.amdgcn.s.nop(i16)