diff --git a/flang/lib/Lower/OpenACC.cpp b/flang/lib/Lower/OpenACC.cpp
--- a/flang/lib/Lower/OpenACC.cpp
+++ b/flang/lib/Lower/OpenACC.cpp
@@ -2305,6 +2305,53 @@
   createSimpleOp<Op>(firOpBuilder, currentLocation, operands, operandSegments);
 }
 
+void genACCSetOp(Fortran::lower::AbstractConverter &converter,
+                 mlir::Location currentLocation,
+                 const Fortran::parser::AccClauseList &accClauseList) {
+  mlir::Value ifCond, deviceNum, defaultAsync;
+  llvm::SmallVector<mlir::Value> deviceTypeOperands;
+
+  fir::FirOpBuilder &firOpBuilder = converter.getFirOpBuilder();
+  Fortran::lower::StatementContext stmtCtx;
+
+  // Lower clauses values mapped to operands.
+  // Keep track of each group of operands separately as clauses can appear
+  // more than once.
+  for (const Fortran::parser::AccClause &clause : accClauseList.v) {
+    mlir::Location clauseLocation = converter.genLocation(clause.source);
+    if (const auto *ifClause =
+            std::get_if<Fortran::parser::AccClause::If>(&clause.u)) {
+      genIfClause(converter, clauseLocation, ifClause, ifCond, stmtCtx);
+    } else if (const auto *defaultAsyncClause =
+                   std::get_if<Fortran::parser::AccClause::DefaultAsync>(
+                       &clause.u)) {
+      defaultAsync = fir::getBase(converter.genExprValue(
+          *Fortran::semantics::GetExpr(defaultAsyncClause->v), stmtCtx));
+    } else if (const auto *deviceNumClause =
+                   std::get_if<Fortran::parser::AccClause::DeviceNum>(
+                       &clause.u)) {
+      deviceNum = fir::getBase(converter.genExprValue(
+          *Fortran::semantics::GetExpr(deviceNumClause->v), stmtCtx));
+    } else if (const auto *deviceTypeClause =
+                   std::get_if<Fortran::parser::AccClause::DeviceType>(
+                       &clause.u)) {
+      genDeviceTypeClause(converter, clauseLocation, deviceTypeClause,
+                          deviceTypeOperands, stmtCtx);
+    }
+  }
+
+  // Prepare the operand segment size attribute and the operands value range.
+  llvm::SmallVector<mlir::Value> operands;
+  llvm::SmallVector<int32_t, 4> operandSegments;
+  addOperands(operands, operandSegments, deviceTypeOperands);
+  addOperand(operands, operandSegments, defaultAsync);
+  addOperand(operands, operandSegments, deviceNum);
+  addOperand(operands, operandSegments, ifCond);
+
+  createSimpleOp<mlir::acc::SetOp>(firOpBuilder, currentLocation, operands,
+                                   operandSegments);
+}
+
 static void
 genACCUpdateOp(Fortran::lower::AbstractConverter &converter,
                mlir::Location currentLocation,
@@ -2425,7 +2472,7 @@
     genACCInitShutdownOp<mlir::acc::ShutdownOp>(converter, currentLocation,
                                                 accClauseList);
   } else if (standaloneDirective.v == llvm::acc::Directive::ACCD_set) {
-    TODO(currentLocation, "OpenACC set directive not lowered yet!");
+    genACCSetOp(converter, currentLocation, accClauseList);
   } else if (standaloneDirective.v == llvm::acc::Directive::ACCD_update) {
     genACCUpdateOp(converter, currentLocation, semanticsContext, stmtCtx,
                    accClauseList);
diff --git a/flang/test/Lower/OpenACC/acc-set.f90 b/flang/test/Lower/OpenACC/acc-set.f90
new file mode 100644
--- /dev/null
+++ b/flang/test/Lower/OpenACC/acc-set.f90
@@ -0,0 +1,40 @@
+! This test checks lowering of OpenACC set directive.
+
+! RUN: bbc -fopenacc -emit-fir %s -o - | FileCheck %s
+
+program test_acc_set
+  logical :: l
+
+!$acc set default_async(1)
+
+!$acc set default_async(1) if(l)
+
+!$acc set device_num(0)
+
+!$acc set device_type(*)
+
+!$acc set device_type(0)
+
+end
+
+! CHECK-LABEL: func.func @_QQmain()
+! CHECK: %[[L:.*]] = fir.alloca !fir.logical<4> {bindc_name = "l", uniq_name = "_QFEl"}
+
+! CHECK: %[[C1:.*]] = arith.constant 1 : i32
+! CHECK: acc.set default_async(%[[C1]] : i32)
+
+! CHECK: %[[C1:.*]] = arith.constant 1 : i32
+! CHECK: %[[LOAD_L:.*]] = fir.load %[[L]] : !fir.ref<!fir.logical<4>>
+! CHECK: %[[CONV_L:.*]] = fir.convert %[[LOAD_L]] : (!fir.logical<4>) -> i1
+! CHECK: acc.set default_async(%[[C1]] : i32) if(%[[CONV_L]])
+
+! CHECK: %[[C0:.*]] = arith.constant 0 : i32
+! CHECK: acc.set device_num(%[[C0]] : i32)
+
+! CHECK: %[[C_1:.*]] = arith.constant -1 : index
+! CHECK: acc.set device_type(%[[C_1]] : index)
+
+! CHECK: %[[C0:.*]] = arith.constant 0 : i32
+! CHECK: acc.set device_type(%[[C0]] : i32)
+
+