Index: llvm/lib/Target/X86/X86TargetTransformInfo.cpp
===================================================================
--- llvm/lib/Target/X86/X86TargetTransformInfo.cpp
+++ llvm/lib/Target/X86/X86TargetTransformInfo.cpp
@@ -6049,6 +6049,10 @@
   if (RealCallerBits == RealCalleeBits)
     return true;
 
+  // If the callee is only missing VLX, they are compatible.
+  if (RealCallerBits == (RealCalleeBits | FeatureBitset{X86::FeatureVLX}))
+    return true;
+
   // If the features are a subset, we need to additionally check for calls
   // that may become ABI-incompatible as a result of inlining.
   if ((RealCallerBits & RealCalleeBits) != RealCalleeBits)
Index: llvm/test/Transforms/Inline/X86/call-abi-compatibility.ll
===================================================================
--- llvm/test/Transforms/Inline/X86/call-abi-compatibility.ll
+++ llvm/test/Transforms/Inline/X86/call-abi-compatibility.ll
@@ -93,3 +93,21 @@
 }
 
 declare i64 @caller_unknown_simple(i64)
+
+; This call should get inlined, because the callee is only missing VLX.
+define void @caller_vlx() "target-features"="+avx512f,+avx512vl" {
+; CHECK-LABEL: define {{[^@]+}}@caller_vlx
+; CHECK-SAME: () #[[ATTR2:[0-9]+]] {
+; CHECK-NEXT:    call void @callee_not_vlx(<8 x i64> <i64 0, i64 1, i64 2, i64 3, i64 4, i64 5, i64 6, i64 7>)
+; CHECK-NEXT:    ret void
+;
+  call void @caller_not_vlx(<8 x i64> <i64 0, i64 1, i64 2, i64 3, i64 4, i64 5, i64 6, i64 7>)
+  ret void
+}
+
+define internal void @caller_not_vlx(<8 x i64> %arg) "target-features"="+avx512f" {
+  call void @callee_not_vlx(<8 x i64> %arg)
+  ret void
+}
+
+declare void @callee_not_vlx(<8 x i64>)