diff --git a/clang/lib/Basic/Targets/OSTargets.cpp b/clang/lib/Basic/Targets/OSTargets.cpp
--- a/clang/lib/Basic/Targets/OSTargets.cpp
+++ b/clang/lib/Basic/Targets/OSTargets.cpp
@@ -226,25 +226,15 @@
     }
   }

-  if (Opts.MicrosoftExt) {
-    Builder.defineMacro("_MSC_EXTENSIONS");
-
-    if (Opts.CPlusPlus11) {
-      Builder.defineMacro("_RVALUE_REFERENCES_V2_SUPPORTED");
-      Builder.defineMacro("_RVALUE_REFERENCES_SUPPORTED");
-      Builder.defineMacro("_NATIVE_NULLPTR_SUPPORTED");
-    }
-  }
-
   if (!Opts.MSVolatile)
     Builder.defineMacro("_ISO_VOLATILE");

   if (Opts.Kernel)
     Builder.defineMacro("_KERNEL_MODE");

   Builder.defineMacro("_INTEGRAL_MAX_BITS", "64");
   Builder.defineMacro("__STDC_NO_THREADS__");

   // Starting with VS 2022 17.1, MSVC predefines the below macro to inform
   // users of the execution character set defined at compile time.
   // The value given is the Windows Code Page Identifier:
@@ -264,7 +254,17 @@
   else if (Triple.isKnownWindowsMSVCEnvironment() ||
            (Triple.isWindowsItaniumEnvironment() && Opts.MSVCCompat))
     addVisualCDefines(Opts, Builder);
+
+  if (Opts.MicrosoftExt) {
+    Builder.defineMacro("_MSC_EXTENSIONS");
+
+    if (Opts.CPlusPlus11) {
+      Builder.defineMacro("_RVALUE_REFERENCES_V2_SUPPORTED");
+      Builder.defineMacro("_RVALUE_REFERENCES_SUPPORTED");
+      Builder.defineMacro("_NATIVE_NULLPTR_SUPPORTED");
+    }
+  }
 }

 } // namespace targets
 } // namespace clang
diff --git a/clang/test/Preprocessor/predefined-win-macros.c b/clang/test/Preprocessor/predefined-win-macros.c
--- a/clang/test/Preprocessor/predefined-win-macros.c
+++ b/clang/test/Preprocessor/predefined-win-macros.c
@@ -120,9 +120,14 @@
 // CHECK-AMD64-MINGW: #define _WIN32 1
 // CHECK-AMD64-MINGW: #define _WIN64 1

+// RUN: %clang_cc1 -triple x86_64-windows-gnu %s -E -dM -o - -fms-extensions \
+// RUN:   | FileCheck -match-full-lines %s --check-prefix=CHECK-AMD64-MINGW-MSE
+
+// CHECK-AMD64-MINGW-MSE: #define _MSC_EXTENSIONS 1
+
 // RUN: %clang_cc1 -triple aarch64-windows-gnu %s -E -dM -o - \
 // RUN:   | FileCheck -match-full-lines %s --check-prefix=CHECK-ARM64-MINGW

 // CHECK-ARM64-MINGW-NOT: #define _M_ARM64 1
 // CHECK-ARM64-MINGW: #define WIN32 1
 // CHECK-ARM64-MINGW: #define WIN64 1