diff --git a/clang/lib/StaticAnalyzer/Checkers/ArrayBoundCheckerV2.cpp b/clang/lib/StaticAnalyzer/Checkers/ArrayBoundCheckerV2.cpp
--- a/clang/lib/StaticAnalyzer/Checkers/ArrayBoundCheckerV2.cpp
+++ b/clang/lib/StaticAnalyzer/Checkers/ArrayBoundCheckerV2.cpp
@@ -172,13 +172,18 @@
     return;
 
   NonLoc ByteOffset = RawOffset->getByteOffset();
+  const SubRegion *Reg = RawOffset->getRegion();
 
   // CHECK LOWER BOUND
-  const MemSpaceRegion *SR = RawOffset->getRegion()->getMemorySpace();
-  if (!llvm::isa<UnknownSpaceRegion>(SR)) {
-    // A pointer to UnknownSpaceRegion may point to the middle of
-    // an allocated region.
-
+  const MemSpaceRegion *Space = Reg->getMemorySpace();
+  if (!(isa<SymbolicRegion>(Reg) && isa<UnknownSpaceRegion>(Space))) {
+    // A symbolic region in unknown space represents an unknown pointer that
+    // may point into the middle of an array, so we don't look for underflows.
+    // Both conditions are significant because we want to check underflows in
+    // symbolic regions on the heap (which may be introduced by checkers like
+    // MallocChecker that call SValBuilder::getConjuredHeapSymbolVal()) and
+    // non-symbolic regions (e.g. a field subregion of a symbolic region) in
+    // unknown space.
     auto [state_precedesLowerBound, state_withinLowerBound] =
         compareValueToThreshold(state, ByteOffset,
                                 svalBuilder.makeZeroArrayIndex(), svalBuilder);
@@ -195,7 +200,7 @@
 
   // CHECK UPPER BOUND
   DefinedOrUnknownSVal Size =
-      getDynamicExtent(state, RawOffset->getRegion(), svalBuilder);
+      getDynamicExtent(state, Reg, svalBuilder);
   if (auto KnownSize = Size.getAs<NonLoc>()) {
     auto [state_withinUpperBound, state_exceedsUpperBound] =
         compareValueToThreshold(state, ByteOffset, *KnownSize, svalBuilder);
diff --git a/clang/test/Analysis/out-of-bounds.c b/clang/test/Analysis/out-of-bounds.c
--- a/clang/test/Analysis/out-of-bounds.c
+++ b/clang/test/Analysis/out-of-bounds.c
@@ -151,11 +151,23 @@
 // Don't warn when indexing below the start of a symbolic region's whose
 // base extent we don't know.
 int *get_symbolic(void);
-void test_index_below_symboloc(void) {
+void test_underflow_symbolic(void) {
   int *buf = get_symbolic();
   buf[-1] = 0; // no-warning;
 }
 
+// But warn if we understand the internal memory layout of a symbolic region.
+typedef struct {
+  int id;
+  char name[256];
+} user_t;
+
+user_t *get_symbolic_user(void);
+char test_underflow_symbolic_2() {
+  user_t *user = get_symbolic_user();
+  return user->name[-1]; // expected-warning{{Out of bound memory access}}
+}
+
 void test_incomplete_struct(void) {
   extern struct incomplete incomplete;
   int *p = (int *)&incomplete;