Index: llvm/lib/Transforms/InstCombine/InstCombineCalls.cpp
===================================================================
--- llvm/lib/Transforms/InstCombine/InstCombineCalls.cpp
+++ llvm/lib/Transforms/InstCombine/InstCombineCalls.cpp
@@ -1518,8 +1518,23 @@
     if (match(IIOperand, m_Select(m_Value(), m_Neg(m_Value(X)), m_Deferred(X))))
       return replaceOperand(*II, 0, X);
 
+    // abs(x-y) --> y-x where x <= y
+    Value *Y;
+    if (match(IIOperand, m_NSWSub(m_Value(X), m_Value(Y)))) {
+      if (std::optional<bool> Known =
+              isImpliedByDomCondition(ICmpInst::ICMP_SLE, X, Y, II, DL)) {
+        if (!*Known)
+          return replaceInstUsesWith(*II, IIOperand);
+
+        // nsw is not permitted if the abs allows INT_MIN.
+        if (IntMinIsPoison)
+          return BinaryOperator::CreateNSWSub(Y, X);
+        return BinaryOperator::CreateSub(Y, X);
+      }
+    }
+
     if (std::optional<bool> Sign = getKnownSign(IIOperand, II, DL, &AC, &DT)) {
-      // abs(x) -> x if x >= 0
+      // abs(x) -> x if x >= 0 (include abs(x-y) --> x-y where x >= y)
       if (!*Sign)
         return replaceInstUsesWith(*II, IIOperand);
 
Index: llvm/test/Transforms/InstCombine/abs-intrinsic.ll
===================================================================
--- llvm/test/Transforms/InstCombine/abs-intrinsic.ll
+++ llvm/test/Transforms/InstCombine/abs-intrinsic.ll
@@ -485,10 +485,10 @@
 ; CHECK-NEXT:    [[CMP:%.*]] = icmp slt i32 [[X:%.*]], [[Y:%.*]]
 ; CHECK-NEXT:    br i1 [[CMP]], label [[COND_TRUE:%.*]], label [[COND_END:%.*]]
 ; CHECK:       cond.true:
-; CHECK-NEXT:    [[SUB_NEG:%.*]] = sub i32 [[Y]], [[X]]
+; CHECK-NEXT:    [[TMP0:%.*]] = sub nsw i32 [[Y]], [[X]]
 ; CHECK-NEXT:    br label [[COND_END]]
 ; CHECK:       cond.end:
-; CHECK-NEXT:    [[R:%.*]] = phi i32 [ [[SUB_NEG]], [[COND_TRUE]] ], [ 0, [[ENTRY:%.*]] ]
+; CHECK-NEXT:    [[R:%.*]] = phi i32 [ [[TMP0]], [[COND_TRUE]] ], [ 0, [[ENTRY:%.*]] ]
 ; CHECK-NEXT:    ret i32 [[R]]
 ;
 entry:
@@ -512,8 +512,7 @@
 ; CHECK-NEXT:    [[CMP_NOT:%.*]] = icmp sgt i32 [[X:%.*]], [[Y:%.*]]
 ; CHECK-NEXT:    br i1 [[CMP_NOT]], label [[COND_END:%.*]], label [[COND_TRUE:%.*]]
 ; CHECK:       cond.true:
-; CHECK-NEXT:    [[SUB:%.*]] = sub nsw i32 [[X]], [[Y]]
-; CHECK-NEXT:    [[TMP0:%.*]] = call i32 @llvm.abs.i32(i32 [[SUB]], i1 true)
+; CHECK-NEXT:    [[TMP0:%.*]] = sub nsw i32 [[Y]], [[X]]
 ; CHECK-NEXT:    br label [[COND_END]]
 ; CHECK:       cond.end:
 ; CHECK-NEXT:    [[R:%.*]] = phi i32 [ [[TMP0]], [[COND_TRUE]] ], [ 0, [[ENTRY:%.*]] ]
@@ -533,16 +532,69 @@
   ret i32 %r
 }
 
+; https://alive2.llvm.org/ce/z/xlpSO0
+define i8 @src_sub_abs_sleF(i8 %x, i8 %y) {
+; CHECK-LABEL: @src_sub_abs_sleF(
+; CHECK-NEXT:  entry:
+; CHECK-NEXT:    [[CMP_NOT:%.*]] = icmp sgt i8 [[X:%.*]], [[Y:%.*]]
+; CHECK-NEXT:    br i1 [[CMP_NOT]], label [[COND_END:%.*]], label [[COND_TRUE:%.*]]
+; CHECK:       cond.true:
+; CHECK-NEXT:    [[TMP0:%.*]] = sub i8 [[Y]], [[X]]
+; CHECK-NEXT:    br label [[COND_END]]
+; CHECK:       cond.end:
+; CHECK-NEXT:    [[R:%.*]] = phi i8 [ [[TMP0]], [[COND_TRUE]] ], [ 0, [[ENTRY:%.*]] ]
+; CHECK-NEXT:    ret i8 [[R]]
+;
+entry:
+  %cmp = icmp sle i8 %x, %y
+  br i1 %cmp, label %cond.true, label %cond.end
+
+cond.true:
+  %sub = sub nsw i8 %x, %y
+  %0 = call i8 @llvm.abs.i8(i8 %sub, i1 false)
+  br label %cond.end
+
+cond.end:
+  %r = phi i8 [ %0, %cond.true ], [ 0, %entry ]
+  ret i8 %r
+}
+
+define i8 @sub_abs_sleT(i8 %x, i8 %y) {
+; CHECK-LABEL: @sub_abs_sleT(
+; CHECK-NEXT:  entry:
+; CHECK-NEXT:    [[CMP_NOT:%.*]] = icmp sgt i8 [[X:%.*]], [[Y:%.*]]
+; CHECK-NEXT:    br i1 [[CMP_NOT]], label [[COND_END:%.*]], label [[COND_TRUE:%.*]]
+; CHECK:       cond.true:
+; CHECK-NEXT:    [[TMP0:%.*]] = sub nsw i8 [[Y]], [[X]]
+; CHECK-NEXT:    br label [[COND_END]]
+; CHECK:       cond.end:
+; CHECK-NEXT:    [[R:%.*]] = phi i8 [ [[TMP0]], [[COND_TRUE]] ], [ 0, [[ENTRY:%.*]] ]
+; CHECK-NEXT:    ret i8 [[R]]
+;
+entry:
+  %cmp = icmp sle i8 %x, %y
+  br i1 %cmp, label %cond.true, label %cond.end
+
+cond.true:
+  %sub = sub nsw i8 %x, %y
+  %0 = call i8 @llvm.abs.i8(i8 %sub, i1 true)
+  br label %cond.end
+
+cond.end:
+  %r = phi i8 [ %0, %cond.true ], [ 0, %entry ]
+  ret i8 %r
+}
+
 define i32 @sub_abs_lt_min_not_poison(i32 %x, i32 %y) {
 ; CHECK-LABEL: @sub_abs_lt_min_not_poison(
 ; CHECK-NEXT:  entry:
 ; CHECK-NEXT:    [[CMP:%.*]] = icmp slt i32 [[X:%.*]], [[Y:%.*]]
 ; CHECK-NEXT:    br i1 [[CMP]], label [[COND_TRUE:%.*]], label [[COND_END:%.*]]
 ; CHECK:       cond.true:
-; CHECK-NEXT:    [[SUB_NEG:%.*]] = sub i32 [[Y]], [[X]]
+; CHECK-NEXT:    [[TMP0:%.*]] = sub i32 [[Y]], [[X]]
 ; CHECK-NEXT:    br label [[COND_END]]
 ; CHECK:       cond.end:
-; CHECK-NEXT:    [[R:%.*]] = phi i32 [ [[SUB_NEG]], [[COND_TRUE]] ], [ 0, [[ENTRY:%.*]] ]
+; CHECK-NEXT:    [[R:%.*]] = phi i32 [ [[TMP0]], [[COND_TRUE]] ], [ 0, [[ENTRY:%.*]] ]
 ; CHECK-NEXT:    ret i32 [[R]]
 ;
 entry: