diff --git a/llvm/lib/Target/BPF/BTFDebug.cpp b/llvm/lib/Target/BPF/BTFDebug.cpp
--- a/llvm/lib/Target/BPF/BTFDebug.cpp
+++ b/llvm/lib/Target/BPF/BTFDebug.cpp
@@ -1006,16 +1006,18 @@
 
 void BTFDebug::constructLineInfo(const DIFile *File, MCSymbol *Label,
                                  uint32_t Line, uint32_t Column) {
-  std::string FileName = populateFileContent(File);
   BTFLineInfo LineInfo;
 
   LineInfo.Label = Label;
-  LineInfo.FileNameOff = addString(FileName);
-  // If file content is not available, let LineOff = 0.
-  if (Line < FileContent[FileName].size())
-    LineInfo.LineOff = addString(FileContent[FileName][Line]);
-  else
-    LineInfo.LineOff = 0;
+  LineInfo.FileNameOff = 0;
+  LineInfo.LineOff = 0;
+  if (File) {
+    std::string FileName = populateFileContent(File);
+    LineInfo.FileNameOff = addString(FileName);
+    // If file content is not available, let LineOff = 0.
+    if (Line < FileContent[FileName].size())
+      LineInfo.LineOff = addString(FileContent[FileName][Line]);
+  }
   LineInfo.LineNum = Line;
   LineInfo.ColumnNum = Column;
   LineInfoTable[SecNameOff].push_back(LineInfo);
@@ -1372,9 +1374,15 @@
     // This instruction will be skipped, no LineInfo has
     // been generated, construct one based on function signature.
     if (LineInfoGenerated == false) {
-      auto *S = MI->getMF()->getFunction().getSubprogram();
+      const Function &F = MI->getMF()->getFunction();
+      auto *S = F.getSubprogram();
       MCSymbol *FuncLabel = Asm->getFunctionBegin();
-      constructLineInfo(S->getFile(), FuncLabel, S->getLine(), 0);
+      // The callee may not have been compiled with debug info.
+      if (S) {
+        constructLineInfo(S->getFile(), FuncLabel, S->getLine(), 0);
+      } else {
+        constructLineInfo(nullptr, FuncLabel, 0, 0);
+      }
       LineInfoGenerated = true;
     }