Index: clang/lib/AST/Interp/Function.h
===================================================================
--- clang/lib/AST/Interp/Function.h
+++ clang/lib/AST/Interp/Function.h
@@ -171,6 +171,17 @@
 
   unsigned getBuiltinID() const { return F->getBuiltinID(); }
 
+  bool isBuiltin() const { return F->getBuiltinID() != 0; }
+
+  bool needsRuntimeArgPop() const {
+    if (!isBuiltin())
+      return false;
+    // FIXME: Is there a better way to get this information?
+    if (getName() == "__builtin_isnan")
+      return true;
+    return false;
+  }
+
   unsigned getNumParams() const { return ParamTypes.size(); }
 
   unsigned getParamOffset(unsigned ParamIndex) const {
Index: clang/lib/AST/Interp/Interp.h
===================================================================
--- clang/lib/AST/Interp/Interp.h
+++ clang/lib/AST/Interp/Interp.h
@@ -200,6 +200,9 @@
 // Returning values
 //===----------------------------------------------------------------------===//
 
+/// Pop arguments of builtins defined as func-name(...).
+bool popBuiltinArgs(InterpState &S, CodePtr OpPC);
+
 template <PrimType Name, class T = typename PrimConv<Name>::T>
 bool Ret(InterpState &S, CodePtr &PC, APValue &Result) {
   const T &Ret = S.Stk.pop<T>();
@@ -216,8 +219,16 @@
   }
 
   assert(S.Current->getFrameOffset() == S.Stk.size() && "Invalid frame");
-  if (!S.checkingPotentialConstantExpression() || S.Current->Caller)
-    S.Current->popArgs();
+  if (!S.checkingPotentialConstantExpression() || S.Current->Caller) {
+    // Certain builtin functions are declared as func-name(...), so the
+    // parameters are checked in Sema and only available through the CallExpr.
+    // The interp::Function we create for them has 0 parameters, so we need to
+    // remove them from the stack by checking the CallExpr.
+    if (S.Current && S.Current->getFunction()->needsRuntimeArgPop())
+      popBuiltinArgs(S, PC);
+    else
+      S.Current->popArgs();
+  }
 
   if (InterpFrame *Caller = S.Current->Caller) {
     PC = S.Current->getRetPC();
Index: clang/lib/AST/Interp/Interp.cpp
===================================================================
--- clang/lib/AST/Interp/Interp.cpp
+++ clang/lib/AST/Interp/Interp.cpp
@@ -122,6 +122,18 @@
 namespace clang {
 namespace interp {
 
+bool popBuiltinArgs(InterpState &S, CodePtr OpPC) {
+  assert(S.Current && S.Current->getFunction()->needsRuntimeArgPop());
+  const Expr *E = S.Current->getExpr(OpPC);
+  assert(isa<CallExpr>(E));
+  const CallExpr *CE = cast<CallExpr>(E);
+  for (const auto &A : CE->arguments()) {
+    PrimType Ty = S.getContext().classify(A->getType()).value_or(PT_Ptr);
+    TYPE_SWITCH(Ty, S.Stk.discard<T>());
+  }
+  return true;
+}
+
 bool CheckExtern(InterpState &S, CodePtr OpPC, const Pointer &Ptr) {
   if (!Ptr.isExtern())
     return true;
Index: clang/lib/AST/Interp/InterpBuiltin.cpp
===================================================================
--- clang/lib/AST/Interp/InterpBuiltin.cpp
+++ clang/lib/AST/Interp/InterpBuiltin.cpp
@@ -158,6 +158,20 @@
   return true;
 }
 
+/// Defined as __builtin_isnan(...), to accommodate the fact that it can
+/// take a float, double, long double, etc.
+/// But for us, that's all a Floating anyway.
+static bool interp__builtin_isnan(InterpState &S, CodePtr OpPC,
+                                  const InterpFrame *Frame, const Function *F) {
+  // FIXME: We are not going through getParam() here, because the function
+  // doesn't have any parameters. Wait for a pattern to emerge and maybe
+  // refactor this into a different function that checks things are valid.
+  const Floating &Arg = S.Stk.peek<Floating>();
+
+  S.Stk.push<Integral<32, true>>(Integral<32, true>::from(Arg.isNan()));
+  return true;
+}
+
 bool InterpretBuiltin(InterpState &S, CodePtr OpPC, const Function *F) {
   InterpFrame *Frame = S.Current;
   APValue Dummy;
@@ -213,6 +227,11 @@
       return Ret<PT_Float>(S, OpPC, Dummy);
     break;
 
+  case Builtin::BI__builtin_isnan:
+    if (interp__builtin_isnan(S, OpPC, Frame, F))
+      return Ret<PT_Sint32>(S, OpPC, Dummy);
+    break;
+
   default:
     return false;
   }
Index: clang/test/Sema/constant-builtins-fmin.cpp
===================================================================
--- clang/test/Sema/constant-builtins-fmin.cpp
+++ clang/test/Sema/constant-builtins-fmin.cpp
@@ -1,4 +1,5 @@
 // RUN: %clang_cc1 -std=c++17 -fsyntax-only -verify %s
+// RUN: %clang_cc1 -std=c++17 -fsyntax-only -verify -fexperimental-new-constant-interpreter %s
 // expected-no-diagnostics
 
 constexpr double NaN = __builtin_nan("");