diff --git a/clang/lib/CodeGen/CGCUDANV.cpp b/clang/lib/CodeGen/CGCUDANV.cpp
--- a/clang/lib/CodeGen/CGCUDANV.cpp
+++ b/clang/lib/CodeGen/CGCUDANV.cpp
@@ -358,9 +358,13 @@
   TranslationUnitDecl *TUDecl = CGM.getContext().getTranslationUnitDecl();
   DeclContext *DC = TranslationUnitDecl::castToDeclContext(TUDecl);
   std::string KernelLaunchAPI = "LaunchKernel";
-  if (CGF.getLangOpts().HIP && CGF.getLangOpts().GPUDefaultStream ==
-                                   LangOptions::GPUDefaultStreamKind::PerThread)
-    KernelLaunchAPI = KernelLaunchAPI + "_spt";
+  if (CGF.getLangOpts().GPUDefaultStream ==
+      LangOptions::GPUDefaultStreamKind::PerThread) {
+    if (CGF.getLangOpts().HIP)
+      KernelLaunchAPI = KernelLaunchAPI + "_spt";
+    else if (CGF.getLangOpts().CUDA)
+      KernelLaunchAPI = KernelLaunchAPI + "_ptsz";
+  }
   auto LaunchKernelName = addPrefixToName(KernelLaunchAPI);
   IdentifierInfo &cudaLaunchKernelII =
       CGM.getContext().Idents.get(LaunchKernelName);
diff --git a/clang/lib/Frontend/InitPreprocessor.cpp b/clang/lib/Frontend/InitPreprocessor.cpp
--- a/clang/lib/Frontend/InitPreprocessor.cpp
+++ b/clang/lib/Frontend/InitPreprocessor.cpp
@@ -574,6 +574,9 @@
       Builder.defineMacro("__CLANG_RDC__");
     if (!LangOpts.HIP)
       Builder.defineMacro("__CUDA__");
+    if (LangOpts.GPUDefaultStream ==
+        LangOptions::GPUDefaultStreamKind::PerThread)
+      Builder.defineMacro("CUDA_API_PER_THREAD_DEFAULT_STREAM");
   }
   if (LangOpts.HIP) {
     Builder.defineMacro("__HIP__");
diff --git a/clang/test/CodeGenCUDA/Inputs/cuda.h b/clang/test/CodeGenCUDA/Inputs/cuda.h
--- a/clang/test/CodeGenCUDA/Inputs/cuda.h
+++ b/clang/test/CodeGenCUDA/Inputs/cuda.h
@@ -58,6 +58,10 @@
 extern "C" cudaError_t cudaLaunchKernel(const void *func, dim3 gridDim,
                                         dim3 blockDim, void **args,
                                         size_t sharedMem, cudaStream_t stream);
+extern "C" cudaError_t cudaLaunchKernel_ptsz(const void *func, dim3 gridDim,
+                                        dim3 blockDim, void **args,
+                                        size_t sharedMem, cudaStream_t stream);
+
 #endif
 
 extern "C" __device__ int printf(const char*, ...);
diff --git a/clang/test/CodeGenCUDA/kernel-call.cu b/clang/test/CodeGenCUDA/kernel-call.cu
--- a/clang/test/CodeGenCUDA/kernel-call.cu
+++ b/clang/test/CodeGenCUDA/kernel-call.cu
@@ -2,6 +2,9 @@
 // RUN: | FileCheck %s --check-prefixes=CUDA-OLD,CHECK
 // RUN: %clang_cc1 -target-sdk-version=9.2  -emit-llvm %s -o - \
 // RUN: | FileCheck %s --check-prefixes=CUDA-NEW,CHECK
+// RUN: %clang_cc1 -target-sdk-version=9.2  -emit-llvm %s -o - \
+// RUN:   -fgpu-default-stream=per-thread -DCUDA_API_PER_THREAD_DEFAULT_STREAM \
+// RUN: | FileCheck %s --check-prefixes=CUDA-PTH,CHECK
 // RUN: %clang_cc1 -x hip -emit-llvm %s -o - \
 // RUN: | FileCheck %s --check-prefixes=HIP-OLD,CHECK
 // RUN: %clang_cc1 -fhip-new-launch-api -x hip -emit-llvm %s -o - \
@@ -25,6 +28,7 @@
 // CUDA-OLD: call{{.*}}cudaLaunch
 // CUDA-NEW: call{{.*}}__cudaPopCallConfiguration
 // CUDA-NEW: call{{.*}}cudaLaunchKernel
+// CUDA-PTH: call{{.*}}cudaLaunchKernel_ptsz
 __global__ void g1(int x) {}
 
 // CHECK-LABEL: define{{.*}}main