diff --git a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
--- a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
@@ -18,6 +18,7 @@
 #include "llvm/Analysis/CmpInstAnalysis.h"
 #include "llvm/Analysis/ConstantFolding.h"
 #include "llvm/Analysis/InstructionSimplify.h"
+#include "llvm/Analysis/ValueTracking.h"
 #include "llvm/Analysis/VectorUtils.h"
 #include "llvm/IR/ConstantRange.h"
 #include "llvm/IR/DataLayout.h"
@@ -3335,6 +3336,63 @@
   return nullptr;
 }
 
+static Instruction *
+foldICmpUSubSatWithConstant(bool ConstantComparisonWithZero,
+                            ICmpInst::Predicate Pred, IntrinsicInst *II,
+                            const APInt &C, InstCombiner::BuilderTy &Builder) {
+  // These transforms may end up producing more than one instruction for the
+  // intrinsic, so limit them to one user.
+  if (!II->hasOneUse())
+    return nullptr;
+
+  // Let Y = usub.sat(X, C) pred C2
+  //  => Y = (X < C ? 0 : (X - C)) pred C2
+  //  => Y = (X < C) ? (0 pred C2) : ((X - C) pred C2)
+  //
+  // When (0 pred C2) [ConstantComparisonWithZero] is true, then
+  //    Y = (X < C) ? true : ((X - C) pred C2)
+  // => Y = (X < C) || ((X - C)) pred C2
+  // else
+  //    Y = (X < C) ? false : ((X - C) pred C2)
+  // => Y = !(X < C) && ((X - C) pred C2)
+  // => Y = (X >= C) && ((X - C) pred C2)
+  Value *Op0 = II->getOperand(0);
+  Value *Op1 = II->getOperand(1);
+
+  auto [NewPred, LogicalOp] =
+      ConstantComparisonWithZero
+          ? std::make_pair(ICmpInst::ICMP_ULT, Instruction::BinaryOps::Or)
+          : std::make_pair(ICmpInst::ICMP_UGE, Instruction::BinaryOps::And);
+
+  const APInt *COp1 = nullptr;
+  if (match(Op1, m_APInt(COp1))) {
+    ConstantRange C1 = ConstantRange::makeExactICmpRegion(NewPred, *COp1);
+    // Convert '(X - C) pred C2' into 'X pred (C + C2)'.
+    ConstantRange C2 = ConstantRange::makeExactICmpRegion(Pred, C);
+    C2 = C2.add(*COp1);
+
+    std::optional<ConstantRange> Combination = std::nullopt;
+    if (LogicalOp == Instruction::BinaryOps::Or)
+      Combination = C1.exactUnionWith(C2);
+    else /* LogicalOp == Instruction::BinaryOp::And */
+      Combination = C1.exactIntersectWith(C2);
+
+    if (Combination) {
+      CmpInst::Predicate EquivPred;
+      APInt EquivInt;
+      APInt EquivOffset;
+      Combination->getEquivalentICmp(EquivPred, EquivInt, EquivOffset);
+
+      return new ICmpInst(
+          EquivPred,
+          Builder.CreateAdd(Op0, ConstantInt::get(Op1->getType(), EquivOffset)),
+          ConstantInt::get(Op1->getType(), EquivInt));
+    }
+  }
+
+  return nullptr;
+}
+
 /// Fold an equality icmp with LLVM intrinsic and constant operand.
 Instruction *InstCombinerImpl::foldICmpEqIntrinsicWithConstant(
     ICmpInst &Cmp, IntrinsicInst *II, const APInt &C) {
@@ -3427,12 +3485,30 @@
       return new ICmpInst(Pred, II->getArgOperand(0), II->getArgOperand(1));
     break;
   case Intrinsic::usub_sat: {
-    // usub.sat(a, b) == 0  ->  a <= b
+    // This is a special case of foldICmpIntrinsicWithConstant.
+    //
+    // Here we have two cases:
+    // - usub.sat(a, b) == c (or)
+    // - usub.sat(a, b) != c
+    //
+    // When c == 0, this simplifies to
+    // - usub.sat(a, b) == 0 ->  a <= b
+    // - usub.sat(a, b) != 0 -> a > b
+    // else we have:
+    // - usub.sat(a, b) == c -> (a >= b) && (a - b) == c (as 0 == c is false)
+    // - usub.sat(a, b) != c -> (a < b) || (a - b) != c (as 0 != c is true)
+    // which is handled by foldICmpUSubSatWithConstant.
+
     if (C.isZero()) {
       ICmpInst::Predicate NewPred =
           Pred == ICmpInst::ICMP_EQ ? ICmpInst::ICMP_ULE : ICmpInst::ICMP_UGT;
       return new ICmpInst(NewPred, II->getArgOperand(0), II->getArgOperand(1));
     }
+
+    if (auto *Folded = foldICmpUSubSatWithConstant(Pred != ICmpInst::ICMP_EQ,
+                                                   Pred, II, C, Builder))
+      return Folded;
+
     break;
   }
   default:
@@ -3657,6 +3733,14 @@
                             II->getArgOperand(1));
     }
     break;
+  case Intrinsic::usub_sat: {
+    if (auto *Folded = foldICmpUSubSatWithConstant(
+            ICmpInst::compare(APInt::getZero(C.getBitWidth()), C, Pred), Pred,
+            II, C, Builder))
+      return Folded;
+
+    break;
+  }
   default:
     break;
   }
diff --git a/llvm/test/Transforms/InstCombine/icmp-usub-sat.ll b/llvm/test/Transforms/InstCombine/icmp-usub-sat.ll
--- a/llvm/test/Transforms/InstCombine/icmp-usub-sat.ll
+++ b/llvm/test/Transforms/InstCombine/icmp-usub-sat.ll
@@ -10,8 +10,7 @@
 define i1 @icmp_eq_basic_positive(i8 %arg) {
 ; CHECK-LABEL: define i1 @icmp_eq_basic_positive
 ; CHECK-SAME: (i8 [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call i8 @llvm.usub.sat.i8(i8 [[ARG]], i8 2)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i8 [[SUB]], 5
+; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i8 [[ARG]], 7
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %sub = call i8 @llvm.usub.sat.i8(i8 %arg, i8 2)
@@ -22,8 +21,7 @@
 define i1 @icmp_ne_basic_positive(i16 %arg) {
 ; CHECK-LABEL: define i1 @icmp_ne_basic_positive
 ; CHECK-SAME: (i16 [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call i16 @llvm.usub.sat.i16(i16 [[ARG]], i16 8)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp ne i16 [[SUB]], 9
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ne i16 [[ARG]], 17
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %sub = call i16 @llvm.usub.sat.i16(i16 %arg, i16 8)
@@ -34,8 +32,7 @@
 define i1 @icmp_ule_basic_positive(i32 %arg) {
 ; CHECK-LABEL: define i1 @icmp_ule_basic_positive
 ; CHECK-SAME: (i32 [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call i32 @llvm.usub.sat.i32(i32 [[ARG]], i32 6)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp ult i32 [[SUB]], 4
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ult i32 [[ARG]], 10
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %sub = call i32 @llvm.usub.sat.i32(i32 %arg, i32 6)
@@ -57,8 +54,7 @@
 define i1 @icmp_uge_basic_positive(i8 %arg) {
 ; CHECK-LABEL: define i1 @icmp_uge_basic_positive
 ; CHECK-SAME: (i8 [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call i8 @llvm.usub.sat.i8(i8 [[ARG]], i8 4)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp ugt i8 [[SUB]], 3
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ugt i8 [[ARG]], 7
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %sub = call i8 @llvm.usub.sat.i8(i8 %arg, i8 4)
@@ -69,8 +65,7 @@
 define i1 @icmp_ugt_basic_positive(i16 %arg) {
 ; CHECK-LABEL: define i1 @icmp_ugt_basic_positive
 ; CHECK-SAME: (i16 [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call i16 @llvm.usub.sat.i16(i16 [[ARG]], i16 1)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp ugt i16 [[SUB]], 3
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ugt i16 [[ARG]], 4
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %sub = call i16 @llvm.usub.sat.i16(i16 %arg, i16 1)
@@ -81,8 +76,8 @@
 define i1 @icmp_sle_basic_positive(i32 %arg) {
 ; CHECK-LABEL: define i1 @icmp_sle_basic_positive
 ; CHECK-SAME: (i32 [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call i32 @llvm.usub.sat.i32(i32 [[ARG]], i32 10)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp slt i32 [[SUB]], 9
+; CHECK-NEXT:    [[TMP1:%.*]] = add i32 [[ARG]], 2147483638
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ult i32 [[TMP1]], -2147483639
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %sub = call i32 @llvm.usub.sat.i32(i32 %arg, i32 10)
@@ -93,8 +88,8 @@
 define i1 @icmp_slt_basic_positive(i64 %arg) {
 ; CHECK-LABEL: define i1 @icmp_slt_basic_positive
 ; CHECK-SAME: (i64 [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call i64 @llvm.usub.sat.i64(i64 [[ARG]], i64 24)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp slt i64 [[SUB]], 5
+; CHECK-NEXT:    [[TMP1:%.*]] = add i64 [[ARG]], 9223372036854775784
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ult i64 [[TMP1]], -9223372036854775803
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %sub = call i64 @llvm.usub.sat.i64(i64 %arg, i64 24)
@@ -105,8 +100,8 @@
 define i1 @icmp_sge_basic_positive(i8 %arg) {
 ; CHECK-LABEL: define i1 @icmp_sge_basic_positive
 ; CHECK-SAME: (i8 [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call i8 @llvm.usub.sat.i8(i8 [[ARG]], i8 1)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp sgt i8 [[SUB]], 3
+; CHECK-NEXT:    [[TMP1:%.*]] = add i8 [[ARG]], -5
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ult i8 [[TMP1]], 124
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %sub = call i8 @llvm.usub.sat.i8(i8 %arg, i8 1)
@@ -117,8 +112,8 @@
 define i1 @icmp_sgt_basic_positive(i16 %arg) {
 ; CHECK-LABEL: define i1 @icmp_sgt_basic_positive
 ; CHECK-SAME: (i16 [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call i16 @llvm.usub.sat.i16(i16 [[ARG]], i16 2)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp sgt i16 [[SUB]], 5
+; CHECK-NEXT:    [[TMP1:%.*]] = add i16 [[ARG]], -8
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ult i16 [[TMP1]], 32762
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %sub = call i16 @llvm.usub.sat.i16(i16 %arg, i16 2)
@@ -152,8 +147,7 @@
 define i1 @icmp_ule_basic_negative(i32 %arg) {
 ; CHECK-LABEL: define i1 @icmp_ule_basic_negative
 ; CHECK-SAME: (i32 [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call i32 @llvm.usub.sat.i32(i32 [[ARG]], i32 -6)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp ult i32 [[SUB]], 4
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ult i32 [[ARG]], -2
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %sub = call i32 @llvm.usub.sat.i32(i32 %arg, i32 -6)
@@ -195,8 +189,7 @@
 define i1 @icmp_sle_basic_negative(i32 %arg) {
 ; CHECK-LABEL: define i1 @icmp_sle_basic_negative
 ; CHECK-SAME: (i32 [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call i32 @llvm.usub.sat.i32(i32 [[ARG]], i32 -10)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp ult i32 [[SUB]], 9
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ne i32 [[ARG]], -1
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %sub = call i32 @llvm.usub.sat.i32(i32 %arg, i32 -10)
@@ -207,8 +200,7 @@
 define i1 @icmp_slt_basic_negative(i64 %arg) {
 ; CHECK-LABEL: define i1 @icmp_slt_basic_negative
 ; CHECK-SAME: (i64 [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call i64 @llvm.usub.sat.i64(i64 [[ARG]], i64 -24)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp ult i64 [[SUB]], 5
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ult i64 [[ARG]], -19
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %sub = call i64 @llvm.usub.sat.i64(i64 %arg, i64 -24)
@@ -586,8 +578,7 @@
 define <2 x i1> @icmp_eq_vector_positive_equal(<2 x i8> %arg) {
 ; CHECK-LABEL: define <2 x i1> @icmp_eq_vector_positive_equal
 ; CHECK-SAME: (<2 x i8> [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call <2 x i8> @llvm.usub.sat.v2i8(<2 x i8> [[ARG]], <2 x i8> <i8 2, i8 2>)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp eq <2 x i8> [[SUB]], <i8 5, i8 5>
+; CHECK-NEXT:    [[CMP:%.*]] = icmp eq <2 x i8> [[ARG]], <i8 7, i8 7>
 ; CHECK-NEXT:    ret <2 x i1> [[CMP]]
 ;
   %sub = call <2 x i8> @llvm.usub.sat.v2i8(<2 x i8> %arg, <2 x i8> <i8 2, i8 2>)
@@ -662,8 +653,7 @@
 define <2 x i1> @icmp_ne_vector_positive_equal(<2 x i16> %arg) {
 ; CHECK-LABEL: define <2 x i1> @icmp_ne_vector_positive_equal
 ; CHECK-SAME: (<2 x i16> [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call <2 x i16> @llvm.usub.sat.v2i16(<2 x i16> [[ARG]], <2 x i16> <i16 32, i16 32>)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp ne <2 x i16> [[SUB]], <i16 5, i16 5>
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ne <2 x i16> [[ARG]], <i16 37, i16 37>
 ; CHECK-NEXT:    ret <2 x i1> [[CMP]]
 ;
   %sub = call <2 x i16> @llvm.usub.sat.v2i16(<2 x i16> %arg, <2 x i16> <i16 32, i16 32>)
@@ -686,8 +676,7 @@
 define <2 x i1> @icmp_ule_vector_positive_equal(<2 x i32> %arg) {
 ; CHECK-LABEL: define <2 x i1> @icmp_ule_vector_positive_equal
 ; CHECK-SAME: (<2 x i32> [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call <2 x i32> @llvm.usub.sat.v2i32(<2 x i32> [[ARG]], <2 x i32> <i32 32, i32 32>)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp ult <2 x i32> [[SUB]], <i32 5, i32 5>
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ult <2 x i32> [[ARG]], <i32 37, i32 37>
 ; CHECK-NEXT:    ret <2 x i1> [[CMP]]
 ;
   %sub = call <2 x i32> @llvm.usub.sat.v2i32(<2 x i32> %arg, <2 x i32> <i32 32, i32 32>)
@@ -710,8 +699,8 @@
 define <2 x i1> @icmp_sgt_vector_positive_equal(<2 x i64> %arg) {
 ; CHECK-LABEL: define <2 x i1> @icmp_sgt_vector_positive_equal
 ; CHECK-SAME: (<2 x i64> [[ARG:%.*]]) {
-; CHECK-NEXT:    [[SUB:%.*]] = call <2 x i64> @llvm.usub.sat.v2i64(<2 x i64> [[ARG]], <2 x i64> <i64 409623, i64 409623>)
-; CHECK-NEXT:    [[CMP:%.*]] = icmp sgt <2 x i64> [[SUB]], <i64 1234, i64 1234>
+; CHECK-NEXT:    [[TMP1:%.*]] = add <2 x i64> [[ARG]], <i64 -410858, i64 -410858>
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ult <2 x i64> [[TMP1]], <i64 9223372036854774573, i64 9223372036854774573>
 ; CHECK-NEXT:    ret <2 x i1> [[CMP]]
 ;
   %sub = call <2 x i64> @llvm.usub.sat.v2i64(<2 x i64> %arg, <2 x i64> <i64 409623, i64 409623>)