diff --git a/llvm/lib/Transforms/InstCombine/InstCombineCalls.cpp b/llvm/lib/Transforms/InstCombine/InstCombineCalls.cpp
--- a/llvm/lib/Transforms/InstCombine/InstCombineCalls.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstCombineCalls.cpp
@@ -2652,6 +2652,7 @@
         isValidAssumeForContext(II, LHS, &DT)) {
       MDNode *MD = MDNode::get(II->getContext(), std::nullopt);
       LHS->setMetadata(LLVMContext::MD_nonnull, MD);
+      LHS->setMetadata(LLVMContext::MD_noundef, MD);
       return RemoveConditionFromAssume(II);
 
       // TODO: apply nonnull return attributes to calls and invokes
diff --git a/llvm/test/Transforms/InstCombine/assume.ll b/llvm/test/Transforms/InstCombine/assume.ll
--- a/llvm/test/Transforms/InstCombine/assume.ll
+++ b/llvm/test/Transforms/InstCombine/assume.ll
@@ -266,7 +266,7 @@
 
 define i1 @nonnull1(ptr %a) {
 ; CHECK-LABEL: @nonnull1(
-; CHECK-NEXT:    [[LOAD:%.*]] = load ptr, ptr [[A:%.*]], align 8, !nonnull !6
+; CHECK-NEXT:    [[LOAD:%.*]] = load ptr, ptr [[A:%.*]], align 8, !nonnull !6, !noundef !6
 ; CHECK-NEXT:    tail call void @escape(ptr nonnull [[LOAD]])
 ; CHECK-NEXT:    ret i1 false
 ;