diff --git a/lldb/source/Host/common/PseudoTerminal.cpp b/lldb/source/Host/common/PseudoTerminal.cpp
--- a/lldb/source/Host/common/PseudoTerminal.cpp
+++ b/lldb/source/Host/common/PseudoTerminal.cpp
@@ -95,7 +95,10 @@
   CloseSecondaryFileDescriptor();
 
   std::string name = GetSecondaryName();
-  m_secondary_fd = llvm::sys::RetryAfterSignal(-1, ::open, name.c_str(), oflag);
+  // Call ::open in a lambda to avoid overload resolution in RetryAfterSignal
+  // when open is overloaded, such as in Bionic.
+  auto Open = [&]() { return ::open(name.c_str(), oflag); };
+  m_secondary_fd = llvm::sys::RetryAfterSignal(-1, Open);
   if (m_secondary_fd >= 0)
     return llvm::Error::success();
 
diff --git a/lldb/source/Host/posix/ConnectionFileDescriptorPosix.cpp b/lldb/source/Host/posix/ConnectionFileDescriptorPosix.cpp
--- a/lldb/source/Host/posix/ConnectionFileDescriptorPosix.cpp
+++ b/lldb/source/Host/posix/ConnectionFileDescriptorPosix.cpp
@@ -726,7 +726,10 @@
 #if LLDB_ENABLE_POSIX
   std::string addr_str = s.str();
   // file:///PATH
-  int fd = llvm::sys::RetryAfterSignal(-1, ::open, addr_str.c_str(), O_RDWR);
+  // Call ::open in a lambda to avoid overload resolution in RetryAfterSignal
+  // when open is overloaded, such as in Bionic.
+  auto Open = [&]() { return ::open(addr_str.c_str(), O_RDWR); };
+  int fd = llvm::sys::RetryAfterSignal(-1, Open);
   if (fd == -1) {
     if (error_ptr)
       error_ptr->SetErrorToErrno();
@@ -776,7 +779,10 @@
     return eConnectionStatusError;
   }
 
-  int fd = llvm::sys::RetryAfterSignal(-1, ::open, path.str().c_str(), O_RDWR);
+  // Call ::open in a lambda to avoid overload resolution in RetryAfterSignal
+  // when open is overloaded, such as in Bionic.
+  auto Open = [&]() { return ::open(path.str().c_str(), O_RDWR); };
+  int fd = llvm::sys::RetryAfterSignal(-1, Open);
   if (fd == -1) {
     if (error_ptr)
       error_ptr->SetErrorToErrno();
diff --git a/lldb/source/Host/posix/FileSystemPosix.cpp b/lldb/source/Host/posix/FileSystemPosix.cpp
--- a/lldb/source/Host/posix/FileSystemPosix.cpp
+++ b/lldb/source/Host/posix/FileSystemPosix.cpp
@@ -77,5 +77,8 @@
 }
 
 int FileSystem::Open(const char *path, int flags, int mode) {
-  return llvm::sys::RetryAfterSignal(-1, ::open, path, flags, mode);
+  // Call ::open in a lambda to avoid overload resolution in RetryAfterSignal
+  // when open is overloaded, such as in Bionic.
+  auto Open = [&]() { return ::open(path, flags, mode); };
+  return llvm::sys::RetryAfterSignal(-1, Open);
 }
diff --git a/lldb/source/Host/posix/PipePosix.cpp b/lldb/source/Host/posix/PipePosix.cpp
--- a/lldb/source/Host/posix/PipePosix.cpp
+++ b/lldb/source/Host/posix/PipePosix.cpp
@@ -148,7 +148,10 @@
     flags |= O_CLOEXEC;
 
   Status error;
-  int fd = llvm::sys::RetryAfterSignal(-1, ::open, name.str().c_str(), flags);
+  // Call ::open in a lambda to avoid overload resolution in RetryAfterSignal
+  // when open is overloaded, such as in Bionic.
+  auto Open = [&]() { return ::open(name.str().c_str(), flags); };
+  int fd = llvm::sys::RetryAfterSignal(-1, Open);
   if (fd != -1)
     m_fds[READ] = fd;
   else
diff --git a/lldb/source/Host/posix/ProcessLauncherPosixFork.cpp b/lldb/source/Host/posix/ProcessLauncherPosixFork.cpp
--- a/lldb/source/Host/posix/ProcessLauncherPosixFork.cpp
+++ b/lldb/source/Host/posix/ProcessLauncherPosixFork.cpp
@@ -71,7 +71,10 @@
 }
 
 static void DupDescriptor(int error_fd, const char *file, int fd, int flags) {
-  int target_fd = llvm::sys::RetryAfterSignal(-1, ::open, file, flags, 0666);
+  // Call ::open in a lambda to avoid overload resolution in RetryAfterSignal
+  // when open is overloaded, such as in Bionic.
+  auto Open = [&]() { return ::open(file, flags, 0666); };
+  int target_fd = llvm::sys::RetryAfterSignal(-1, Open);
 
   if (target_fd == -1)
     ExitWithError(error_fd, "DupDescriptor-open");