diff --git a/llvm/lib/Analysis/MemoryBuiltins.cpp b/llvm/lib/Analysis/MemoryBuiltins.cpp
--- a/llvm/lib/Analysis/MemoryBuiltins.cpp
+++ b/llvm/lib/Analysis/MemoryBuiltins.cpp
@@ -826,7 +826,7 @@
 }
 
 SizeOffsetType ObjectSizeOffsetVisitor::visitGlobalVariable(GlobalVariable &GV){
-  if (!GV.hasDefinitiveInitializer())
+  if (!GV.hasInitializer() || GV.isInterposable())
     return unknown();
 
   APInt Size(IntTyBits, DL.getTypeAllocSize(GV.getValueType()));
diff --git a/llvm/test/Transforms/InstSimplify/gv-externally-initializable.ll b/llvm/test/Transforms/InstSimplify/gv-externally-initializable.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/InstSimplify/gv-externally-initializable.ll
@@ -0,0 +1,35 @@
+; NOTE: Assertions have been autogenerated by utils/update_test_checks.py UTC_ARGS: --version 2
+; RUN: opt < %s -passes=instsimplify -S | FileCheck %s
+
+@gv = global i64 zeroinitializer, align 16
+
+define i1 @cmp_gv_alloca() {
+; CHECK-LABEL: define i1 @cmp_gv_alloca() {
+; CHECK-NEXT:    ret i1 false
+;
+  %alloca = alloca i64, align 8
+  %cmp = icmp eq ptr %alloca, @gv
+  ret i1 %cmp
+}
+
+@gv_externally_init = externally_initialized global i64 zeroinitializer, align 16
+
+define i1 @cmp_gv_alloca_extern_init() {
+; CHECK-LABEL: define i1 @cmp_gv_alloca_extern_init() {
+; CHECK-NEXT:    ret i1 false
+;
+  %alloca = alloca i64, align 8
+  %cmp = icmp eq ptr %alloca, @gv_externally_init
+  ret i1 %cmp
+}
+
+@const_gv = protected addrspace(4) externally_initialized global [4096 x i64] zeroinitializer, align 16
+define i1 @cmp_gv_alloca_cast() {
+; CHECK-LABEL: define i1 @cmp_gv_alloca_cast() {
+; CHECK-NEXT:    ret i1 false
+;
+  %alloca = alloca i64, align 8, addrspace(5)
+  %cast.alloca = addrspacecast ptr addrspace(5) %alloca to ptr
+  %cmp = icmp eq ptr %cast.alloca, addrspacecast (ptr addrspace(4) @const_gv to ptr)
+  ret i1 %cmp
+}