diff --git a/llvm/lib/Support/KnownBits.cpp b/llvm/lib/Support/KnownBits.cpp
--- a/llvm/lib/Support/KnownBits.cpp
+++ b/llvm/lib/Support/KnownBits.cpp
@@ -546,6 +546,13 @@
   assert(!LHS.hasConflict() && !RHS.hasConflict() && "Bad inputs");
   KnownBits Known(BitWidth);
 
+  if (LHS.isZero() || RHS.isZero() ||
+      (LHS.getSignedMaxValue().isMinSignedValue() && RHS.isAllOnes())) {
+    // Result is either known Zero or Poison. Return Zero either way.
+    Known.setAllZero();
+    return Known;
+  }
+
   std::optional<APInt> Res;
   if (LHS.isNegative() && RHS.isNegative()) {
     // Result non-negative.
@@ -607,6 +614,12 @@
   assert(!LHS.hasConflict() && !RHS.hasConflict());
   KnownBits Known(BitWidth);
 
+  if (LHS.isZero() || RHS.isZero()) {
+    // Result is either known Zero or Poison. Return Zero either way.
+    Known.setAllZero();
+    return Known;
+  }
+
   // We can figure out the minimum number of upper zero bits by doing
   // MaxNumerator / MinDenominator. If the Numerator gets smaller or Denominator
   // gets larger, the number of upper zero bits increases.
diff --git a/llvm/test/CodeGen/WebAssembly/pr59626.ll b/llvm/test/CodeGen/WebAssembly/pr59626.ll
--- a/llvm/test/CodeGen/WebAssembly/pr59626.ll
+++ b/llvm/test/CodeGen/WebAssembly/pr59626.ll
@@ -13,6 +13,9 @@
 ; CHECK-32-NEXT:    i32.const 0
 ; CHECK-32-NEXT:    i32.store16 0
 ; CHECK-32-NEXT:    local.get 1
+; CHECK-32-NEXT:    i32.const 0
+; CHECK-32-NEXT:    i32.store8 2
+; CHECK-32-NEXT:    local.get 1
 ; CHECK-32-NEXT:    local.get 0
 ; CHECK-32-NEXT:    i8x16.splat
 ; CHECK-32-NEXT:    v128.store16_lane 0, 0