diff --git a/llvm/lib/Transforms/Scalar/GVNHoist.cpp b/llvm/lib/Transforms/Scalar/GVNHoist.cpp
--- a/llvm/lib/Transforms/Scalar/GVNHoist.cpp
+++ b/llvm/lib/Transforms/Scalar/GVNHoist.cpp
@@ -246,6 +246,7 @@
                                       LLVMContext::MD_fpmath,
                                       LLVMContext::MD_invariant_load,
                                       LLVMContext::MD_invariant_group,
+                                      LLVMContext::MD_prof,
                                       LLVMContext::MD_access_group};
   combineMetadata(ReplInst, I, KnownIDs, true);
 }
diff --git a/llvm/lib/Transforms/Scalar/MemCpyOptimizer.cpp b/llvm/lib/Transforms/Scalar/MemCpyOptimizer.cpp
--- a/llvm/lib/Transforms/Scalar/MemCpyOptimizer.cpp
+++ b/llvm/lib/Transforms/Scalar/MemCpyOptimizer.cpp
@@ -1091,6 +1091,7 @@
   // handled here, but combineMetadata doesn't support them yet
   unsigned KnownIDs[] = {LLVMContext::MD_tbaa, LLVMContext::MD_alias_scope,
                          LLVMContext::MD_noalias,
+                         LLVMContext::MD_prof,
                          LLVMContext::MD_invariant_group,
                          LLVMContext::MD_access_group};
   combineMetadata(C, cpyLoad, KnownIDs, true);