diff --git a/mlir/include/mlir/Tools/mlir-opt/MlirOptMain.h b/mlir/include/mlir/Tools/mlir-opt/MlirOptMain.h
--- a/mlir/include/mlir/Tools/mlir-opt/MlirOptMain.h
+++ b/mlir/include/mlir/Tools/mlir-opt/MlirOptMain.h
@@ -228,27 +228,6 @@
                           DialectRegistry &registry,
                           const MlirOptMainConfig &config);
 
-/// Perform the core processing behind `mlir-opt`.
-/// This API is deprecated, use the MlirOptMainConfig version above instead.
-LogicalResult MlirOptMain(llvm::raw_ostream &outputStream,
-                          std::unique_ptr<llvm::MemoryBuffer> buffer,
-                          const PassPipelineCLParser &passPipeline,
-                          DialectRegistry &registry, bool splitInputFile,
-                          bool verifyDiagnostics, bool verifyPasses,
-                          bool allowUnregisteredDialects,
-                          bool preloadDialectsInContext = false,
-                          bool emitBytecode = false, bool explicitModule = true,
-                          bool dumpPassPipeline = false);
-
-/// Perform the core processing behind `mlir-opt`.
-/// This API is deprecated, use the MlirOptMainConfig version above instead.
-LogicalResult MlirOptMain(
-    llvm::raw_ostream &outputStream, std::unique_ptr<llvm::MemoryBuffer> buffer,
-    PassPipelineFn passManagerSetupFn, DialectRegistry &registry,
-    bool splitInputFile, bool verifyDiagnostics, bool verifyPasses,
-    bool allowUnregisteredDialects, bool preloadDialectsInContext = false,
-    bool emitBytecode = false, bool explicitModule = true);
-
 /// Implementation for tools like `mlir-opt`.
 /// - toolName is used for the header displayed by `--help`.
 /// - registry should contain all the dialects that can be parsed in the source.
diff --git a/mlir/lib/Tools/mlir-opt/MlirOptMain.cpp b/mlir/lib/Tools/mlir-opt/MlirOptMain.cpp
--- a/mlir/lib/Tools/mlir-opt/MlirOptMain.cpp
+++ b/mlir/lib/Tools/mlir-opt/MlirOptMain.cpp
@@ -427,45 +427,6 @@
                                /*insertMarkerInOutput=*/true);
 }
 
-LogicalResult mlir::MlirOptMain(raw_ostream &outputStream,
-                                std::unique_ptr<MemoryBuffer> buffer,
-                                PassPipelineFn passManagerSetupFn,
-                                DialectRegistry &registry, bool splitInputFile,
-                                bool verifyDiagnostics, bool verifyPasses,
-                                bool allowUnregisteredDialects,
-                                bool preloadDialectsInContext,
-                                bool emitBytecode, bool explicitModule) {
-  return MlirOptMain(outputStream, std::move(buffer), registry,
-                     MlirOptMainConfig{}
-                         .splitInputFile(splitInputFile)
-                         .verifyDiagnostics(verifyDiagnostics)
-                         .verifyPasses(verifyPasses)
-                         .allowUnregisteredDialects(allowUnregisteredDialects)
-                         .preloadDialectsInContext(preloadDialectsInContext)
-                         .emitBytecode(emitBytecode)
-                         .useExplicitModule(explicitModule)
-                         .setPassPipelineSetupFn(passManagerSetupFn));
-}
-
-LogicalResult mlir::MlirOptMain(
-    raw_ostream &outputStream, std::unique_ptr<MemoryBuffer> buffer,
-    const PassPipelineCLParser &passPipeline, DialectRegistry &registry,
-    bool splitInputFile, bool verifyDiagnostics, bool verifyPasses,
-    bool allowUnregisteredDialects, bool preloadDialectsInContext,
-    bool emitBytecode, bool explicitModule, bool dumpPassPipeline) {
-  return MlirOptMain(outputStream, std::move(buffer), registry,
-                     MlirOptMainConfig{}
-                         .splitInputFile(splitInputFile)
-                         .verifyDiagnostics(verifyDiagnostics)
-                         .verifyPasses(verifyPasses)
-                         .allowUnregisteredDialects(allowUnregisteredDialects)
-                         .preloadDialectsInContext(preloadDialectsInContext)
-                         .emitBytecode(emitBytecode)
-                         .useExplicitModule(explicitModule)
-                         .dumpPassPipeline(dumpPassPipeline)
-                         .setPassPipelineParser(passPipeline));
-}
-
 LogicalResult mlir::MlirOptMain(int argc, char **argv, llvm::StringRef toolName,
                                 DialectRegistry &registry,
                                 bool preloadDialectsInContext) {