diff --git a/clang/lib/Driver/ToolChains/Clang.cpp b/clang/lib/Driver/ToolChains/Clang.cpp
--- a/clang/lib/Driver/ToolChains/Clang.cpp
+++ b/clang/lib/Driver/ToolChains/Clang.cpp
@@ -740,6 +740,12 @@
     PGOGenerateArg = nullptr;
   }
 
+  if (TC.getTriple().isOSAIX()) {
+    if (Arg *ProfileSampleUseArg = getLastProfileSampleUseArg(Args))
+      D.Diag(diag::err_drv_unsupported_opt_for_target)
+          << ProfileSampleUseArg->getSpelling() << TC.getTriple().str();
+  }
+
   if (ProfileGenerateArg) {
     if (ProfileGenerateArg->getOption().matches(
             options::OPT_fprofile_instr_generate_EQ))
diff --git a/clang/test/Driver/unsupported-option.c b/clang/test/Driver/unsupported-option.c
--- a/clang/test/Driver/unsupported-option.c
+++ b/clang/test/Driver/unsupported-option.c
@@ -13,3 +13,7 @@
 // RUN: not %clang --target=powerpc64-ibm-aix %s -mlong-double-128 2>&1 | \
 // RUN: FileCheck %s --check-prefix=AIX64-LONGDOUBLE128-ERR
 // AIX64-LONGDOUBLE128-ERR: error: unsupported option '-mlong-double-128' for target 'powerpc64-ibm-aix'
+
+// RUN: not %clang -fprofile-sample-use=code.prof --target=powerpc-ibm-aix %s 2>&1 | \
+// RUN: FileCheck %s --check-prefix=AIX-PROFILE-SAMPLE
+// AIX-PROFILE-SAMPLE: error: unsupported option '-fprofile-sample-use=' for target