diff --git a/clang/lib/AST/Interp/ByteCodeExprGen.cpp b/clang/lib/AST/Interp/ByteCodeExprGen.cpp
--- a/clang/lib/AST/Interp/ByteCodeExprGen.cpp
+++ b/clang/lib/AST/Interp/ByteCodeExprGen.cpp
@@ -223,8 +223,12 @@
 
   // Deal with operations which have composite or void types.
   if (BO->isCommaOp()) {
-    if (!discard(LHS))
+    if (!this->discard(LHS))
       return false;
+    if (RHS->getType()->isVoidType())
+      return this->discard(RHS);
+
+    // Otherwise, visit RHS and optionally discard its value.
     return Discard(this->visit(RHS));
   }
 
@@ -1642,10 +1646,12 @@
   if (!visit(Exp))
     return false;
 
+  if (Exp->getType()->isVoidType())
+    return this->emitRetVoid(Exp);
+
   if (std::optional<PrimType> T = classify(Exp))
     return this->emitRet(*T, Exp);
-  else
-    return this->emitRetValue(Exp);
+  return this->emitRetValue(Exp);
 }
 
 /// Toplevel visitDecl().
diff --git a/clang/test/AST/Interp/literals.cpp b/clang/test/AST/Interp/literals.cpp
--- a/clang/test/AST/Interp/literals.cpp
+++ b/clang/test/AST/Interp/literals.cpp
@@ -855,9 +855,23 @@
   (a); // expected-warning {{unused}} \
        // ref-warning {{unused}}
 
+  (void)5, (void)6;
+
   return 0;
 }
 
+/// Ignored comma expressions still have their
+/// expressions evaluated.
+constexpr int Comma(int start) {
+    int i = start;
+
+    (void)i++;
+    (void)i++,(void)i++;
+    return i;
+}
+constexpr int Value = Comma(5);
+static_assert(Value == 8, "");
+
 #endif
 
 namespace PredefinedExprs {