diff --git a/llvm/lib/Transforms/Utils/SimplifyCFG.cpp b/llvm/lib/Transforms/Utils/SimplifyCFG.cpp
--- a/llvm/lib/Transforms/Utils/SimplifyCFG.cpp
+++ b/llvm/lib/Transforms/Utils/SimplifyCFG.cpp
@@ -1588,9 +1588,12 @@
       // a return.
       auto *C1 = dyn_cast<CallInst>(I1);
       auto *C2 = dyn_cast<CallInst>(I2);
-      if (C1 && C2)
+      if (C1 && C2) {
         if (C1->isMustTailCall() != C2->isMustTailCall())
           return Changed;
+        if (C1->getMetadata(LLVMContext::MD_prof) || C2->getMetadata(LLVMContext::MD_prof))
+          return Changed;
+      }
 
       if (!TTI.isProfitableToHoist(I1) || !TTI.isProfitableToHoist(I2))
         return Changed;
@@ -1798,9 +1801,12 @@
     // and merging inline-asm instructions can potentially create arguments
     // that cannot satisfy the inline-asm constraints.
     // If the instruction has nomerge or convergent attribute, return false.
-    if (const auto *C = dyn_cast<CallBase>(I))
+    if (const auto *C = dyn_cast<CallBase>(I)) {
       if (C->isInlineAsm() || C->cannotMerge() || C->isConvergent())
         return false;
+      if (C->getMetadata(LLVMContext::MD_prof))
+        return false;
+    }
 
     // Each instruction must have zero or one use.
     if (HasUse && !I->hasOneUse())