diff --git a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
--- a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
@@ -1953,6 +1953,27 @@
     return new ICmpInst(NewPred, X, NewC);
   }
 
+  const APInt* LHS;
+  // icmp(X | LHS, C) --> icmp(X, 0) iff LHS > C s>= 0
+  if (match(Or, m_c_Or(m_Value(X), m_APInt(LHS)))) {
+    if (LHS->isStrictlyPositive() && C.isNonNegative() && LHS->sgt(C)) {
+      switch (Pred) {
+      // X | RHS s<= C --> X s< C
+      case ICmpInst::ICMP_SLE:
+      // X | RHS s< C --> X s< C
+      case ICmpInst::ICMP_SLT:
+        return new ICmpInst(ICmpInst::ICMP_SLT, X, ConstantInt::getNullValue(X->getType()));
+      // X | RHS s>= C --> X s>= C
+      case ICmpInst::ICMP_SGE:
+      // X | RHS s> C --> X s>= C
+      case ICmpInst::ICMP_SGT:
+        return new ICmpInst(ICmpInst::ICMP_SGE, X, ConstantInt::getNullValue(X->getType()));
+      default:
+        break;
+      }
+    }
+  }
+
   if (!Cmp.isEquality() || !C.isZero() || !Or->hasOneUse())
     return nullptr;
 
diff --git a/llvm/test/Transforms/InstCombine/icmp.ll b/llvm/test/Transforms/InstCombine/icmp.ll
--- a/llvm/test/Transforms/InstCombine/icmp.ll
+++ b/llvm/test/Transforms/InstCombine/icmp.ll
@@ -4631,8 +4631,7 @@
 define i1 @mul_or_constant_sgt(i8 %a, i8 %b) {
 ; CHECK-LABEL: @mul_or_constant_sgt(
 ; CHECK-NEXT:    [[MUL1:%.*]] = mul i8 [[A:%.*]], [[B:%.*]]
-; CHECK-NEXT:    [[ADD:%.*]] = or i8 [[MUL1]], 24
-; CHECK-NEXT:    [[CMP:%.*]] = icmp sgt i8 [[ADD]], 0
+; CHECK-NEXT:    [[CMP:%.*]] = icmp sgt i8 [[MUL1]], -1
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %mul1 = mul i8 %a, %b
@@ -4644,8 +4643,7 @@
 define <2 x i1> @mul_or_constant_vec_sgt(<2 x i8> %a, <2 x i8> %b) {
 ; CHECK-LABEL: @mul_or_constant_vec_sgt(
 ; CHECK-NEXT:    [[MUL1:%.*]] = mul <2 x i8> [[A:%.*]], [[B:%.*]]
-; CHECK-NEXT:    [[ADD:%.*]] = or <2 x i8> [[MUL1]], <i8 24, i8 24>
-; CHECK-NEXT:    [[CMP:%.*]] = icmp sgt <2 x i8> [[ADD]], zeroinitializer
+; CHECK-NEXT:    [[CMP:%.*]] = icmp sgt <2 x i8> [[MUL1]], <i8 -1, i8 -1>
 ; CHECK-NEXT:    ret <2 x i1> [[CMP]]
 ;
 
@@ -4669,8 +4667,7 @@
 define i1 @mul_or_constant_sle(i8 %a, i8 %b) {
 ; CHECK-LABEL: @mul_or_constant_sle(
 ; CHECK-NEXT:    [[MUL1:%.*]] = mul i8 [[A:%.*]], [[B:%.*]]
-; CHECK-NEXT:    [[ADD:%.*]] = or i8 [[MUL1]], 24
-; CHECK-NEXT:    [[CMP:%.*]] = icmp slt i8 [[ADD]], 1
+; CHECK-NEXT:    [[CMP:%.*]] = icmp slt i8 [[MUL1]], 0
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %mul1 = mul i8 %a, %b
@@ -4682,8 +4679,7 @@
 define <2 x i1> @mul_or_constant_vec_sle(<2 x i8> %a, <2 x i8> %b) {
 ; CHECK-LABEL: @mul_or_constant_vec_sle(
 ; CHECK-NEXT:    [[MUL1:%.*]] = mul <2 x i8> [[A:%.*]], [[B:%.*]]
-; CHECK-NEXT:    [[ADD:%.*]] = or <2 x i8> [[MUL1]], <i8 24, i8 24>
-; CHECK-NEXT:    [[CMP:%.*]] = icmp slt <2 x i8> [[ADD]], <i8 1, i8 1>
+; CHECK-NEXT:    [[CMP:%.*]] = icmp slt <2 x i8> [[MUL1]], zeroinitializer
 ; CHECK-NEXT:    ret <2 x i1> [[CMP]]
 ;