diff --git a/lldb/bindings/python/python-typemaps.swig b/lldb/bindings/python/python-typemaps.swig
--- a/lldb/bindings/python/python-typemaps.swig
+++ b/lldb/bindings/python/python-typemaps.swig
@@ -103,11 +103,11 @@
 
 // typemap for a char buffer
 %typemap(in) (char *dst, size_t dst_len) {
-  if (!PyInt_Check($input)) {
+  if (!PyLong_Check($input)) {
     PyErr_SetString(PyExc_ValueError, "Expecting an integer");
     SWIG_fail;
   }
-  $2 = PyInt_AsLong($input);
+  $2 = PyLong_AsLong($input);
   if ($2 <= 0) {
     PyErr_SetString(PyExc_ValueError, "Positive integer expected");
     SWIG_fail;
@@ -139,11 +139,11 @@
 
 // typemap for handling an snprintf-like API like SBThread::GetStopDescription.
 %typemap(in) (char *dst_or_null, size_t dst_len) {
-  if (!PyInt_Check($input)) {
+  if (!PyLong_Check($input)) {
     PyErr_SetString(PyExc_ValueError, "Expecting an integer");
     SWIG_fail;
   }
-  $2 = PyInt_AsLong($input);
+  $2 = PyLong_AsLong($input);
   if ($2 <= 0) {
     PyErr_SetString(PyExc_ValueError, "Positive integer expected");
     SWIG_fail;
@@ -205,9 +205,7 @@
 // typemap for an incoming buffer
 // See also SBProcess::ReadMemory.
 %typemap(in) (void *buf, size_t size) {
-  if (PyInt_Check($input)) {
-    $2 = PyInt_AsLong($input);
-  } else if (PyLong_Check($input)) {
+  if (PyLong_Check($input)) {
     $2 = PyLong_AsLong($input);
   } else {
     PyErr_SetString(PyExc_ValueError, "Expecting an integer or long object");
@@ -258,9 +256,7 @@
 }
 
 template <class T> bool SetNumberFromPyObject(T &number, PyObject *obj) {
-  if (PyInt_Check(obj))
-    number = static_cast<T>(PyInt_AsLong(obj));
-  else if (PyLong_Check(obj))
+  if (PyLong_Check(obj))
     number = PyLongAsT<T>(obj);
   else
     return false;
@@ -345,7 +341,7 @@
     count = $2;
   PyObject *list = PyList_New(count);
   for (uint32_t j = 0; j < count; j++) {
-    PyObject *item = PyInt_FromLong($1[j]);
+    PyObject *item = PyLong_FromLong($1[j]);
     int ok = PyList_SetItem(list, j, item);
     if (ok != 0) {
       $result = Py_None;
diff --git a/lldb/test/API/python_api/sbdata/TestSBData.py b/lldb/test/API/python_api/sbdata/TestSBData.py
--- a/lldb/test/API/python_api/sbdata/TestSBData.py
+++ b/lldb/test/API/python_api/sbdata/TestSBData.py
@@ -387,12 +387,13 @@
         self.assert_data(data2.GetUnsignedInt8, 4, 111)
         self.assert_data(data2.GetUnsignedInt8, 5, 33)
 
-        data2.SetDataFromUInt64Array([1, 2, 3, 4, 5])
+        data2.SetDataFromUInt64Array([1, 2, 3, 4, 5, 2**63])
         self.assert_data(data2.GetUnsignedInt64, 0, 1)
         self.assert_data(data2.GetUnsignedInt64, 8, 2)
         self.assert_data(data2.GetUnsignedInt64, 16, 3)
         self.assert_data(data2.GetUnsignedInt64, 24, 4)
         self.assert_data(data2.GetUnsignedInt64, 32, 5)
+        self.assert_data(data2.GetUnsignedInt64, 40, 2**63)
 
         self.assertEqual(
             data2.uint64[0], 1,