diff --git a/llvm/lib/Passes/PassBuilderPipelines.cpp b/llvm/lib/Passes/PassBuilderPipelines.cpp
--- a/llvm/lib/Passes/PassBuilderPipelines.cpp
+++ b/llvm/lib/Passes/PassBuilderPipelines.cpp
@@ -968,14 +968,6 @@
   if (Level == OptimizationLevel::O3)
     EarlyFPM.addPass(CallSiteSplittingPass());
 
-  // In SamplePGO ThinLTO backend, we need instcombine before profile annotation
-  // to convert bitcast to direct calls so that they can be inlined during the
-  // profile annotation prepration step.
-  // More details about SamplePGO design can be found in:
-  // https://research.google.com/pubs/pub45290.html
-  // FIXME: revisit how SampleProfileLoad/Inliner/ICP is structured.
-  if (LoadSampleProfile)
-    EarlyFPM.addPass(InstCombinePass());
   MPM.addPass(createModuleToFunctionPassAdaptor(std::move(EarlyFPM),
                                                 PTO.EagerlyInvalidateAnalyses));
 
diff --git a/llvm/test/Other/new-pm-pgo.ll b/llvm/test/Other/new-pm-pgo.ll
--- a/llvm/test/Other/new-pm-pgo.ll
+++ b/llvm/test/Other/new-pm-pgo.ll
@@ -24,7 +24,6 @@
 ; SAMPLE_USE: Running pass: SimplifyCFGPass
 ; SAMPLE_USE: Running pass: SROAPass
 ; SAMPLE_USE: Running pass: EarlyCSEPass
-; SAMPLE_USE_POST_LINK: Running pass: InstCombinePass
 ; SAMPLE_USE: Running pass: SampleProfileLoaderPass
 ; SAMPLE_USE_O: Running pass: PGOIndirectCallPromotion
 ; SAMPLE_USE_POST_LINK-NOT: Running pass: GlobalOptPass
diff --git a/llvm/test/Other/new-pm-thinlto-postlink-samplepgo-defaults.ll b/llvm/test/Other/new-pm-thinlto-postlink-samplepgo-defaults.ll
--- a/llvm/test/Other/new-pm-thinlto-postlink-samplepgo-defaults.ll
+++ b/llvm/test/Other/new-pm-thinlto-postlink-samplepgo-defaults.ll
@@ -44,18 +44,12 @@
 ; CHECK-O-NEXT: Running pass: EarlyCSEPass
 ; CHECK-O-NEXT: Running analysis: TargetLibraryAnalysis
 ; CHECK-O3-NEXT: Running pass: CallSiteSplittingPass
-; CHECK-O-NEXT: Running pass: InstCombinePass on foo
-; CHECK-O-NEXT: Running analysis: OptimizationRemarkEmitterAnalysis on foo
-; CHECK-O-NEXT: Running analysis: AAManager on foo
-; CHECK-O-NEXT: Running analysis: BasicAA
-; CHECK-O-NEXT: Running analysis: ScopedNoAliasAA
-; CHECK-O-NEXT: Running analysis: TypeBasedAA
-; CHECK-O-NEXT: Running analysis: OuterAnalysisManagerProxy
 ; CHECK-O-NEXT: Running pass: SampleProfileLoaderPass
 ; CHECK-O-NEXT: Running analysis: ProfileSummaryAnalysis
 ; CHECK-O-NEXT: Running analysis: CallGraphAnalysis
 ; CHECK-O-NEXT: Running pass: RequireAnalysisPass<{{.*}}ProfileSummaryAnalysis
 ; CHECK-O-NEXT: Running pass: PGOIndirectCallPromotion
+; CHECK-O-NEXT: Running analysis: OptimizationRemarkEmitterAnalysis
 ; CHECK-O-NEXT: Running pass: OpenMPOptPass
 ; CHECK-O-NEXT: Running pass: LowerTypeTestsPass
 ; CHECK-O-NEXT: Running pass: IPSCCPPass
@@ -64,6 +58,11 @@
 ; CHECK-O-NEXT: Running pass: GlobalOptPass
 ; CHECK-O-NEXT: Running pass: PromotePass
 ; CHECK-O-NEXT: Running pass: InstCombinePass
+; CHECK-O-NEXT: Running analysis: AAManager on foo
+; CHECK-O-NEXT: Running analysis: BasicAA
+; CHECK-O-NEXT: Running analysis: ScopedNoAliasAA
+; CHECK-O-NEXT: Running analysis: TypeBasedAA
+; CHECK-O-NEXT: Running analysis: OuterAnalysisManagerProxy
 ; CHECK-O-NEXT: Running analysis: BlockFrequencyAnalysis on foo
 ; These next two can appear in any order since they are accessed as parameters
 ; on the same call to BlockFrequencyInfo::calculate.
diff --git a/llvm/test/Other/new-pm-thinlto-prelink-samplepgo-defaults.ll b/llvm/test/Other/new-pm-thinlto-prelink-samplepgo-defaults.ll
--- a/llvm/test/Other/new-pm-thinlto-prelink-samplepgo-defaults.ll
+++ b/llvm/test/Other/new-pm-thinlto-prelink-samplepgo-defaults.ll
@@ -42,13 +42,6 @@
 ; CHECK-O-NEXT: Running pass: EarlyCSEPass
 ; CHECK-O-NEXT: Running analysis: TargetLibraryAnalysis
 ; CHECK-O3-NEXT: Running pass: CallSiteSplittingPass
-; CHECK-O-NEXT: Running pass: InstCombinePass on foo
-; CHECK-O-NEXT: Running analysis: OptimizationRemarkEmitterAnalysis on foo
-; CHECK-O-NEXT: Running analysis: AAManager on foo
-; CHECK-O-NEXT: Running analysis: BasicAA
-; CHECK-O-NEXT: Running analysis: ScopedNoAliasAA
-; CHECK-O-NEXT: Running analysis: TypeBasedAA
-; CHECK-O-NEXT: Running analysis: OuterAnalysisManagerProxy
 ; CHECK-O-NEXT: Running pass: SampleProfileLoaderPass
 ; CHECK-O-NEXT: Running analysis: ProfileSummaryAnalysis
 ; CHECK-O-NEXT: Running analysis: CallGraphAnalysis
@@ -59,6 +52,12 @@
 ; CHECK-O-NEXT: Running pass: GlobalOptPass
 ; CHECK-O-NEXT: Running pass: PromotePass
 ; CHECK-O-NEXT: Running pass: InstCombinePass
+; CHECK-O-NEXT: Running analysis: OptimizationRemarkEmitterAnalysis on foo
+; CHECK-O-NEXT: Running analysis: AAManager on foo
+; CHECK-O-NEXT: Running analysis: BasicAA
+; CHECK-O-NEXT: Running analysis: ScopedNoAliasAA
+; CHECK-O-NEXT: Running analysis: TypeBasedAA
+; CHECK-O-NEXT: Running analysis: OuterAnalysisManagerProxy
 ; CHECK-O-NEXT: Running analysis: BlockFrequencyAnalysis on foo
 ; These next two can appear in any order since they are accessed as parameters
 ; on the same call to BlockFrequencyInfo::calculate.