diff --git a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
--- a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
@@ -4065,20 +4065,36 @@
   return Res;
 }
 
-static Instruction *foldICmpXNegX(ICmpInst &I) {
+static Instruction *foldICmpXNegX(ICmpInst &I,
+                                  InstCombiner::BuilderTy &Builder) {
   CmpInst::Predicate Pred;
   Value *X;
-  if (!match(&I, m_c_ICmp(Pred, m_NSWNeg(m_Value(X)), m_Deferred(X))))
-    return nullptr;
+  if (match(&I, m_c_ICmp(Pred, m_NSWNeg(m_Value(X)), m_Deferred(X)))) {
 
-  if (ICmpInst::isSigned(Pred))
-    Pred = ICmpInst::getSwappedPredicate(Pred);
-  else if (ICmpInst::isUnsigned(Pred))
-    Pred = ICmpInst::getSignedPredicate(Pred);
-  // else for equality-comparisons just keep the predicate.
+    if (ICmpInst::isSigned(Pred))
+      Pred = ICmpInst::getSwappedPredicate(Pred);
+    else if (ICmpInst::isUnsigned(Pred))
+      Pred = ICmpInst::getSignedPredicate(Pred);
+    // else for equality-comparisons just keep the predicate.
+
+    return ICmpInst::Create(Instruction::ICmp, Pred, X,
+                            Constant::getNullValue(X->getType()), I.getName());
+  }
 
-  return ICmpInst::Create(Instruction::ICmp, Pred, X,
-                          Constant::getNullValue(X->getType()), I.getName());
+  // A value is not equal to its negation unless that value is 0 or
+  // MinSignedValue, ie: a != -a --> (a & MaxSignedVal) != 0
+  if (match(&I, m_c_ICmp(Pred, m_OneUse(m_Neg(m_Value(X))), m_Deferred(X))) &&
+      ICmpInst::isEquality(Pred)) {
+    Type *Ty = X->getType();
+    uint32_t BitWidth = Ty->getScalarSizeInBits();
+    Constant *MaxSignedVal =
+        ConstantInt::get(Ty, APInt::getSignedMaxValue(BitWidth));
+    Value *And = Builder.CreateAnd(X, MaxSignedVal);
+    Constant *Zero = Constant::getNullValue(Ty);
+    return CmpInst::Create(Instruction::ICmp, Pred, And, Zero);
+  }
+
+  return nullptr;
 }
 
 /// Try to fold icmp (binop), X or icmp X, (binop).
@@ -4096,7 +4112,7 @@
   if (!BO0 && !BO1)
     return nullptr;
 
-  if (Instruction *NewICmp = foldICmpXNegX(I))
+  if (Instruction *NewICmp = foldICmpXNegX(I, Builder))
     return NewICmp;
 
   const CmpInst::Predicate Pred = I.getPredicate();
diff --git a/llvm/test/Transforms/InstCombine/icmp-sub.ll b/llvm/test/Transforms/InstCombine/icmp-sub.ll
--- a/llvm/test/Transforms/InstCombine/icmp-sub.ll
+++ b/llvm/test/Transforms/InstCombine/icmp-sub.ll
@@ -566,8 +566,8 @@
 define i1 @PR60818_ne(i32 %a) {
 ; CHECK-LABEL: @PR60818_ne(
 ; CHECK-NEXT:  entry:
-; CHECK-NEXT:    [[SUB:%.*]] = sub i32 0, [[A:%.*]]
-; CHECK-NEXT:    [[CMP:%.*]] = icmp ne i32 [[SUB]], [[A]]
+; CHECK-NEXT:    [[TMP0:%.*]] = and i32 [[A:%.*]], 2147483647
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ne i32 [[TMP0]], 0
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
 entry:
@@ -579,8 +579,8 @@
 define i1 @PR60818_eq(i32 %a) {
 ; CHECK-LABEL: @PR60818_eq(
 ; CHECK-NEXT:  entry:
-; CHECK-NEXT:    [[SUB:%.*]] = sub i32 0, [[A:%.*]]
-; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i32 [[SUB]], [[A]]
+; CHECK-NEXT:    [[TMP0:%.*]] = and i32 [[A:%.*]], 2147483647
+; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i32 [[TMP0]], 0
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
 entry:
@@ -593,8 +593,8 @@
 ; CHECK-LABEL: @PR60818_eq_commuted(
 ; CHECK-NEXT:  entry:
 ; CHECK-NEXT:    [[A:%.*]] = mul i32 [[X:%.*]], 43
-; CHECK-NEXT:    [[SUB:%.*]] = sub i32 0, [[A]]
-; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i32 [[A]], [[SUB]]
+; CHECK-NEXT:    [[TMP0:%.*]] = and i32 [[A]], 2147483647
+; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i32 [[TMP0]], 0
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
 entry:
@@ -607,8 +607,8 @@
 define <2 x i1> @PR60818_ne_vector(<2 x i32> %a) {
 ; CHECK-LABEL: @PR60818_ne_vector(
 ; CHECK-NEXT:  entry:
-; CHECK-NEXT:    [[SUB:%.*]] = sub <2 x i32> zeroinitializer, [[A:%.*]]
-; CHECK-NEXT:    [[CMP:%.*]] = icmp ne <2 x i32> [[SUB]], [[A]]
+; CHECK-NEXT:    [[TMP0:%.*]] = and <2 x i32> [[A:%.*]], <i32 2147483647, i32 2147483647>
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ne <2 x i32> [[TMP0]], zeroinitializer
 ; CHECK-NEXT:    ret <2 x i1> [[CMP]]
 ;
 entry: