diff --git a/clang/lib/Driver/ToolChains/Clang.cpp b/clang/lib/Driver/ToolChains/Clang.cpp
--- a/clang/lib/Driver/ToolChains/Clang.cpp
+++ b/clang/lib/Driver/ToolChains/Clang.cpp
@@ -6164,8 +6164,19 @@
   Args.AddLastArg(CmdArgs, options::OPT_femit_all_decls);
   Args.AddLastArg(CmdArgs, options::OPT_fheinous_gnu_extensions);
   Args.AddLastArg(CmdArgs, options::OPT_fdigraphs, options::OPT_fno_digraphs);
-  Args.AddLastArg(CmdArgs, options::OPT_femulated_tls,
-                  options::OPT_fno_emulated_tls);
+
+  if (Arg *A = Args.getLastArg(options::OPT_femulated_tls,
+                               options::OPT_fno_emulated_tls)) {
+    // LLVM does not support Emulated TLS for some architectures, like RISCV
+    // So issue an error to avoid subtle problems in codegen if the flags are
+    // incompatible. see https://github.com/llvm/llvm-project/issues/59500
+    if (!Triple.supportsEmulatedTLS() &&
+        A->getOption().getID() == options::OPT_femulated_tls)
+      D.Diag(diag::err_drv_unsupported_opt_for_target)
+          << A->getAsString(Args) << TripleStr;
+    A->render(Args, CmdArgs);
+  }
+
   Args.AddLastArg(CmdArgs, options::OPT_fzero_call_used_regs_EQ);
 
   if (Arg *A = Args.getLastArg(options::OPT_fzero_call_used_regs_EQ)) {
diff --git a/clang/test/Driver/emulated-tls.cpp b/clang/test/Driver/emulated-tls.cpp
--- a/clang/test/Driver/emulated-tls.cpp
+++ b/clang/test/Driver/emulated-tls.cpp
@@ -29,6 +29,10 @@
 // RUN: %clang -### -target i686-pc-openbsd %s -femulated-tls -fno-emulated-tls 2>&1 \
 // RUN: | FileCheck -check-prefix=NOEMU %s
 
+// RUN: %clang -### --target=riscv64-linux-android %s -fno-emulated-tls 2>&1 \
+// RUN: | FileCheck -check-prefix=RISCV %s
+// RUN: %clang -### --target=riscv64-linux-android %s -fno-emulated-tls -femulated-tls 2>&1 \
+// RUN: | FileCheck -check-prefix=RISCV-ERROR %s
 
 // Default without -f[no-]emulated-tls, will be decided by the target triple.
 // DEFAULT-NOT: "-cc1" {{.*}}"-femulated-tls"
@@ -40,3 +44,6 @@
 
 // NOEMU: "-cc1" {{.*}}"-fno-emulated-tls"
 // NOEMU-NOT: "-cc1" {{.*}}"-femulated-tls"
+
+// RISCV-NOT: error: unsupported option '-fno-emulated-tls' for target 'riscv64-unknown-linux-android'
+// RISCV-ERROR: error: unsupported option '-femulated-tls' for target 'riscv64-unknown-linux-android'