diff --git a/lldb/bindings/python/python-typemaps.swig b/lldb/bindings/python/python-typemaps.swig
--- a/lldb/bindings/python/python-typemaps.swig
+++ b/lldb/bindings/python/python-typemaps.swig
@@ -384,6 +384,29 @@
   $1 = $1 || PyCallable_Check(reinterpret_cast<PyObject *>($input));
 }
 
+// For lldb::SBDebuggerDestroyCallback
+%typemap(in) (lldb::SBDebuggerDestroyCallback destroy_callback, void *baton) {
+  if (!($input == Py_None ||
+        PyCallable_Check(reinterpret_cast<PyObject *>($input)))) {
+    PyErr_SetString(PyExc_TypeError, "Need a callable object or None!");
+    SWIG_fail;
+  }
+
+  // FIXME (filcab): We can't currently check if our callback is already
+  // LLDBSwigPythonCallPythonSBDebuggerTerminateCallback (to DECREF the previous
+  // baton) nor can we just remove all traces of a callback, if we want to
+  // revert to a file logging mechanism.
+
+  // Don't lose the callback reference
+  Py_INCREF($input);
+  $1 = LLDBSwigPythonCallPythonSBDebuggerTerminateCallback;
+  $2 = $input;
+}
+
+%typemap(typecheck) (lldb::SBDebuggerDestroyCallback destroy_callback, void *baton) {
+  $1 = $input == Py_None;
+  $1 = $1 || PyCallable_Check(reinterpret_cast<PyObject *>($input));
+}
 
 %typemap(in) lldb::FileSP {
   PythonFile py_file(PyRefType::Borrowed, $input);
diff --git a/lldb/bindings/python/python-wrapper.swig b/lldb/bindings/python/python-wrapper.swig
--- a/lldb/bindings/python/python-wrapper.swig
+++ b/lldb/bindings/python/python-wrapper.swig
@@ -1062,4 +1062,16 @@
     SWIG_PYTHON_THREAD_END_BLOCK;
   }
 }
+
+// For DebuggerTerminateCallback functions
+static void LLDBSwigPythonCallPythonSBDebuggerTerminateCallback(lldb::user_id_t debugger_id,
+                                                      void *baton) {
+  if (baton != Py_None) {
+    SWIG_PYTHON_THREAD_BEGIN_BLOCK;
+    PyObject *result = PyObject_CallFunction(
+        reinterpret_cast<PyObject *>(baton), const_cast<char *>("l"), debugger_id);
+    Py_XDECREF(result);
+    SWIG_PYTHON_THREAD_END_BLOCK;
+  }
+}
 %}
diff --git a/lldb/include/lldb/API/SBDebugger.h b/lldb/include/lldb/API/SBDebugger.h
--- a/lldb/include/lldb/API/SBDebugger.h
+++ b/lldb/include/lldb/API/SBDebugger.h
@@ -316,6 +316,9 @@
 
   void SetLoggingCallback(lldb::LogOutputCallback log_callback, void *baton);
 
+  void SetDestroyCallback(lldb::SBDebuggerDestroyCallback destroy_callback,
+                          void *baton);
+
   // DEPRECATED
 #ifndef SWIG
   void DispatchInput(void *baton, const void *data, size_t data_len);
diff --git a/lldb/include/lldb/API/SBDefines.h b/lldb/include/lldb/API/SBDefines.h
--- a/lldb/include/lldb/API/SBDefines.h
+++ b/lldb/include/lldb/API/SBDefines.h
@@ -110,6 +110,10 @@
 typedef bool (*SBBreakpointHitCallback)(void *baton, SBProcess &process,
                                         SBThread &thread,
                                         lldb::SBBreakpointLocation &location);
+
+typedef void (*SBDebuggerDestroyCallback)(lldb::user_id_t debugger_id,
+                                          void *baton);
+
 typedef void *ScriptedObject;
 }
 
diff --git a/lldb/include/lldb/Core/Debugger.h b/lldb/include/lldb/Core/Debugger.h
--- a/lldb/include/lldb/Core/Debugger.h
+++ b/lldb/include/lldb/Core/Debugger.h
@@ -450,6 +450,10 @@
 
   static void ReportSymbolChange(const ModuleSpec &module_spec);
 
+  void
+  SetDestroyCallback(lldb_private::DebuggerDestroyCallback destroy_callback,
+                     void *baton);
+
 protected:
   friend class CommandInterpreter;
   friend class REPL;
@@ -494,6 +498,8 @@
                                    std::optional<lldb::user_id_t> debugger_id,
                                    std::once_flag *once);
 
+  void HandleDestroyCallback();
+
   void PrintProgress(const ProgressEventData &data);
 
   bool StartEventHandlerThread();
@@ -591,6 +597,9 @@
   llvm::once_flag m_clear_once;
   lldb::TargetSP m_dummy_target_sp;
 
+  lldb_private::DebuggerDestroyCallback m_destroy_callback = nullptr;
+  void *m_destroy_callback_baton = nullptr;
+
   // Events for m_sync_broadcaster
   enum {
     eBroadcastBitEventThreadIsListening = (1 << 0),
diff --git a/lldb/include/lldb/lldb-private-types.h b/lldb/include/lldb/lldb-private-types.h
--- a/lldb/include/lldb/lldb-private-types.h
+++ b/lldb/include/lldb/lldb-private-types.h
@@ -116,6 +116,8 @@
 using ValueObjectProviderTy =
     std::function<lldb::ValueObjectSP(ConstString, StackFrame *)>;
 
+typedef void (*DebuggerDestroyCallback)(lldb::user_id_t debugger_id,
+                                        void *baton);
 } // namespace lldb_private
 
 #endif // #if defined(__cplusplus)
diff --git a/lldb/source/API/SBDebugger.cpp b/lldb/source/API/SBDebugger.cpp
--- a/lldb/source/API/SBDebugger.cpp
+++ b/lldb/source/API/SBDebugger.cpp
@@ -1684,6 +1684,15 @@
   }
 }
 
+void SBDebugger::SetDestroyCallback(
+    lldb::SBDebuggerDestroyCallback destroy_callback, void *baton) {
+  LLDB_INSTRUMENT_VA(this, destroy_callback, baton);
+  if (m_opaque_sp) {
+    return m_opaque_sp->SetDestroyCallback(
+        destroy_callback, baton);
+  }
+}
+
 SBTrace
 SBDebugger::LoadTraceFromFile(SBError &error,
                               const SBFileSpec &trace_description_file) {
diff --git a/lldb/source/Core/Debugger.cpp b/lldb/source/Core/Debugger.cpp
--- a/lldb/source/Core/Debugger.cpp
+++ b/lldb/source/Core/Debugger.cpp
@@ -560,6 +560,12 @@
   assert(g_debugger_list_ptr &&
          "Debugger::Terminate called without a matching Debugger::Initialize!");
 
+  if (g_debugger_list_ptr && g_debugger_list_mutex_ptr) {
+    std::lock_guard<std::recursive_mutex> guard(*g_debugger_list_mutex_ptr);
+    for (const auto &debugger : *g_debugger_list_ptr)
+      debugger->HandleDestroyCallback();
+  }
+
   if (g_thread_pool) {
     // The destructor will wait for all the threads to complete.
     delete g_thread_pool;
@@ -679,10 +685,18 @@
   return debugger_sp;
 }
 
+void Debugger::HandleDestroyCallback() {
+  if (m_destroy_callback) {
+    m_destroy_callback(GetID(), m_destroy_callback_baton);
+    m_destroy_callback = nullptr;
+  }
+}
+
 void Debugger::Destroy(DebuggerSP &debugger_sp) {
   if (!debugger_sp)
     return;
 
+  debugger_sp->HandleDestroyCallback();
   CommandInterpreter &cmd_interpreter = debugger_sp->GetCommandInterpreter();
 
   if (cmd_interpreter.GetSaveSessionOnQuit()) {
@@ -1285,6 +1299,12 @@
       std::make_shared<CallbackLogHandler>(log_callback, baton);
 }
 
+void Debugger::SetDestroyCallback(
+    lldb_private::DebuggerDestroyCallback destroy_callback, void *baton) {
+  m_destroy_callback = destroy_callback;
+  m_destroy_callback_baton = baton;
+}
+
 static void PrivateReportProgress(Debugger &debugger, uint64_t progress_id,
                                   std::string title, std::string details,
                                   uint64_t completed, uint64_t total,
diff --git a/lldb/test/API/python_api/debugger/TestDebuggerAPI.py b/lldb/test/API/python_api/debugger/TestDebuggerAPI.py
--- a/lldb/test/API/python_api/debugger/TestDebuggerAPI.py
+++ b/lldb/test/API/python_api/debugger/TestDebuggerAPI.py
@@ -30,7 +30,7 @@
         self.dbg.SetPrompt(None)
         self.dbg.SetCurrentPlatform(None)
         self.dbg.SetCurrentPlatformSDKRoot(None)
-        
+
         fresh_dbg = lldb.SBDebugger()
         self.assertEquals(len(fresh_dbg), 0)
 
@@ -146,3 +146,16 @@
         self.assertEqual(platform2.GetName(), expected_platform)
         self.assertTrue(platform2.GetWorkingDirectory().endswith("bar"),
                 platform2.GetWorkingDirectory())
+
+    def test_SetDestroyCallback(self):
+        destroy_dbg_id = None
+        def foo(dbg_id):
+            # Need nonlocal to modify closure variable.
+            nonlocal destroy_dbg_id
+            destroy_dbg_id = dbg_id
+
+        self.dbg.SetDestroyCallback(foo)
+
+        original_dbg_id = self.dbg.GetID()
+        self.dbg.Destroy(self.dbg)
+        self.assertEqual(destroy_dbg_id,  original_dbg_id)