diff --git a/llvm/lib/Target/AMDGPU/AMDGPUTargetTransformInfo.cpp b/llvm/lib/Target/AMDGPU/AMDGPUTargetTransformInfo.cpp
--- a/llvm/lib/Target/AMDGPU/AMDGPUTargetTransformInfo.cpp
+++ b/llvm/lib/Target/AMDGPU/AMDGPUTargetTransformInfo.cpp
@@ -1175,6 +1175,11 @@
   const int NrOfSGPRUntilSpill = 26;
   const int NrOfVGPRUntilSpill = 32;
 
+  // In case of indirect calls, callee Function may not be retrievable from the
+  // CallBase.
+  if (!Callee)
+    return 0;
+
   const DataLayout &DL = TTIImpl->getDataLayout();
 
   unsigned adjustThreshold = 0;
diff --git a/llvm/test/Transforms/Inline/AMDGPU/amdgpu-inline-stack-indirect-call-argument.ll b/llvm/test/Transforms/Inline/AMDGPU/amdgpu-inline-stack-indirect-call-argument.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/Inline/AMDGPU/amdgpu-inline-stack-indirect-call-argument.ll
@@ -0,0 +1,22 @@
+; REQUIRES: asserts
+; RUN: opt -mtriple=amdgcn-amd-amdhsa -S -passes=inline -inline-cost-full=true -debug-only=inline-cost < %s 2>&1 | FileCheck %s
+
+; CHECK: Analyzing call of Dummy... (caller:Caller) 
+
+define void @Wrapper(ptr nocapture nofree noundef readonly %func, ptr noundef %arg, i32 noundef %a) {
+entry:
+  call void %func(ptr noundef %arg, i32 noundef %a)
+  ret void
+}
+
+define internal void @Dummy(ptr noundef %ptrarg, i32 noundef %intarg) {
+entry:
+  ret void
+}
+
+define void @Caller() {
+entry:
+  %arg = alloca ptr
+  call void @Wrapper(ptr noundef @Dummy, ptr noundef %arg, i32 42)
+  ret void
+}