diff --git a/openmp/libomptarget/plugins-nextgen/amdgpu/CMakeLists.txt b/openmp/libomptarget/plugins-nextgen/amdgpu/CMakeLists.txt
--- a/openmp/libomptarget/plugins-nextgen/amdgpu/CMakeLists.txt
+++ b/openmp/libomptarget/plugins-nextgen/amdgpu/CMakeLists.txt
@@ -90,7 +90,6 @@
 
   NO_INSTALL_RPATH
 )
-add_dependencies(omptarget.rtl.amdgpu.nextgen omptarget.devicertl.amdgpu)
 
 target_include_directories(
   omptarget.rtl.amdgpu.nextgen
diff --git a/openmp/libomptarget/plugins-nextgen/cuda/CMakeLists.txt b/openmp/libomptarget/plugins-nextgen/cuda/CMakeLists.txt
--- a/openmp/libomptarget/plugins-nextgen/cuda/CMakeLists.txt
+++ b/openmp/libomptarget/plugins-nextgen/cuda/CMakeLists.txt
@@ -51,7 +51,6 @@
   target_include_directories(omptarget.rtl.cuda.nextgen PRIVATE ../../plugins/cuda/dynamic_cuda)
   target_sources(omptarget.rtl.cuda.nextgen PRIVATE ../../plugins/cuda/dynamic_cuda/cuda.cpp)
 endif()
-add_dependencies(omptarget.rtl.cuda.nextgen omptarget.devicertl.nvptx)
 
 # Define debug prefix. TODO: This should be automatized in the Debug.h but it
 # requires changing the original plugins.
diff --git a/openmp/libomptarget/plugins/amdgpu/CMakeLists.txt b/openmp/libomptarget/plugins/amdgpu/CMakeLists.txt
--- a/openmp/libomptarget/plugins/amdgpu/CMakeLists.txt
+++ b/openmp/libomptarget/plugins/amdgpu/CMakeLists.txt
@@ -90,7 +90,6 @@
 
   NO_INSTALL_RPATH
 )
-add_dependencies(omptarget.rtl.amdgpu omptarget.devicertl.amdgpu)
 
 target_include_directories(
   omptarget.rtl.amdgpu
diff --git a/openmp/libomptarget/plugins/cuda/CMakeLists.txt b/openmp/libomptarget/plugins/cuda/CMakeLists.txt
--- a/openmp/libomptarget/plugins/cuda/CMakeLists.txt
+++ b/openmp/libomptarget/plugins/cuda/CMakeLists.txt
@@ -50,7 +50,6 @@
   target_include_directories(omptarget.rtl.cuda PRIVATE dynamic_cuda)
   target_sources(omptarget.rtl.cuda PRIVATE dynamic_cuda/cuda.cpp)
 endif()
-add_dependencies(omptarget.rtl.cuda omptarget.devicertl.nvptx)
 
 # Define the suffix for the runtime messaging dumps.
 target_compile_definitions(omptarget.rtl.cuda PRIVATE TARGET_NAME="CUDA")