diff --git a/openmp/libomptarget/include/device.h b/openmp/libomptarget/include/device.h
--- a/openmp/libomptarget/include/device.h
+++ b/openmp/libomptarget/include/device.h
@@ -13,6 +13,7 @@
 #ifndef _OMPTARGET_DEVICE_H
 #define _OMPTARGET_DEVICE_H
 
+#include <atomic>
 #include <cassert>
 #include <cstddef>
 #include <cstdint>
@@ -530,6 +531,32 @@
   /// Flag to indicate if we use events to ensure the atomicity of
   /// map clauses or not. Can be modified with an environment variable.
   const bool UseEventsForAtomicTransfers;
+
+  // Work around for plugins that call dlopen on shared libraries that call
+  // tgt_register_lib during their initialisation. Stash the pointers in a
+  // vector until the plugins are all initialised and then register them.
+  bool maybeDelayRegisterLib(__tgt_bin_desc *Desc) {
+    if (!RTLsLoaded) {
+      // Only reachable from libomptarget constructor
+      DelayedBinDesc.push_back(Desc);
+      return true;
+    } else {
+      return false;
+    }
+  }
+
+  void registerDelayedLibraries() {
+    // Only called by libomptarget constructor
+    for (auto *Desc : DelayedBinDesc) {
+      __tgt_register_lib(Desc);
+    }
+    DelayedBinDesc.clear();
+    RTLsLoaded = true;
+  }
+
+private:
+  std::atomic_bool RTLsLoaded = false;
+  llvm::SmallVector<__tgt_bin_desc *> DelayedBinDesc;
 };
 
 extern PluginManager *PM;
diff --git a/openmp/libomptarget/include/rtl.h b/openmp/libomptarget/include/rtl.h
--- a/openmp/libomptarget/include/rtl.h
+++ b/openmp/libomptarget/include/rtl.h
@@ -171,10 +171,8 @@
   // Unregister a shared library from all RTLs.
   void unregisterLib(__tgt_bin_desc *Desc);
 
-  // Mutex-like object to guarantee thread-safety and unique initialization
-  // (i.e. the library attempts to load the RTLs (plugins) only once).
-  std::once_flag InitFlag;
-  void loadRTLs(); // not thread-safe
+  // not thread-safe, called from global constructor (i.e. once)
+  void loadRTLs();
 
 private:
   static bool attemptLoadRTL(const std::string &RTLName, RTLInfoTy &RTL);
diff --git a/openmp/libomptarget/plugins/remote/server/Server.cpp b/openmp/libomptarget/plugins/remote/server/Server.cpp
--- a/openmp/libomptarget/plugins/remote/server/Server.cpp
+++ b/openmp/libomptarget/plugins/remote/server/Server.cpp
@@ -90,8 +90,6 @@
 Status RemoteOffloadImpl::GetNumberOfDevices(ServerContext *Context,
                                              const Null *Null,
                                              I32 *NumberOfDevices) {
-  std::call_once(PM->RTLs.initFlag, &RTLsTy::LoadRTLs, &PM->RTLs);
-
   int32_t Devices = 0;
   PM->RTLsMtx.lock();
   for (auto &RTL : PM->RTLs.AllRTLs)
diff --git a/openmp/libomptarget/src/interface.cpp b/openmp/libomptarget/src/interface.cpp
--- a/openmp/libomptarget/src/interface.cpp
+++ b/openmp/libomptarget/src/interface.cpp
@@ -35,7 +35,9 @@
 /// adds a target shared library to the target execution image
 EXTERN void __tgt_register_lib(__tgt_bin_desc *Desc) {
   TIMESCOPE();
-  std::call_once(PM->RTLs.InitFlag, &RTLsTy::loadRTLs, &PM->RTLs);
+  if (PM->maybeDelayRegisterLib(Desc)) {
+    return;
+  }
   for (auto &RTL : PM->RTLs.AllRTLs) {
     if (RTL.register_lib) {
       if ((*RTL.register_lib)(Desc) != OFFLOAD_SUCCESS) {
diff --git a/openmp/libomptarget/src/rtl.cpp b/openmp/libomptarget/src/rtl.cpp
--- a/openmp/libomptarget/src/rtl.cpp
+++ b/openmp/libomptarget/src/rtl.cpp
@@ -64,6 +64,9 @@
   // TODO: add a configuration option for time granularity
   if (ProfileTraceFile)
     timeTraceProfilerInitialize(500 /* us */, "libomptarget");
+
+  PM->RTLs.loadRTLs();
+  PM->registerDelayedLibraries();
 }
 
 __attribute__((destructor(101))) void deinit() {