diff --git a/openmp/libomptarget/src/interface.cpp b/openmp/libomptarget/src/interface.cpp
--- a/openmp/libomptarget/src/interface.cpp
+++ b/openmp/libomptarget/src/interface.cpp
@@ -35,7 +35,6 @@
 /// adds a target shared library to the target execution image
 EXTERN void __tgt_register_lib(__tgt_bin_desc *Desc) {
   TIMESCOPE();
-  std::call_once(PM->RTLs.InitFlag, &RTLsTy::loadRTLs, &PM->RTLs);
   for (auto &RTL : PM->RTLs.AllRTLs) {
     if (RTL.register_lib) {
       if ((*RTL.register_lib)(Desc) != OFFLOAD_SUCCESS) {
diff --git a/openmp/libomptarget/src/rtl.cpp b/openmp/libomptarget/src/rtl.cpp
--- a/openmp/libomptarget/src/rtl.cpp
+++ b/openmp/libomptarget/src/rtl.cpp
@@ -39,11 +39,16 @@
     /* Remote target        */ "libomptarget.rtl.rpc",
 };
 
-PluginManager *PM;
+PluginManager *PM = nullptr;
 
 static char *ProfileTraceFile = nullptr;
 
 __attribute__((constructor(101))) void init() {
+  if (PM != nullptr) {
+    // In case one of the plugins chooses to call back into this constructor
+    return;
+  }
+
   DP("Init target library!\n");
 
   bool UseEventsForAtomicTransfers = true;
@@ -64,11 +69,14 @@
   // TODO: add a configuration option for time granularity
   if (ProfileTraceFile)
     timeTraceProfilerInitialize(500 /* us */, "libomptarget");
+
+  PM->RTLs.loadRTLs();
 }
 
 __attribute__((destructor(101))) void deinit() {
   DP("Deinit target library!\n");
   delete PM;
+  PM = nullptr;
 
   if (ProfileTraceFile) {
     // TODO: add env var for file output