diff --git a/openmp/CMakeLists.txt b/openmp/CMakeLists.txt
--- a/openmp/CMakeLists.txt
+++ b/openmp/CMakeLists.txt
@@ -74,7 +74,8 @@
 # Currently libomptarget cannot be compiled on Windows or MacOS X.
 # Since the device plugins are only supported on Linux anyway,
 # there is no point in trying to compile libomptarget on other OSes.
-if (APPLE OR WIN32 OR NOT OPENMP_HAVE_STD_CPP17_FLAG)
+# 32-bit systems are not supported either.
+if (APPLE OR WIN32 OR NOT OPENMP_HAVE_STD_CPP17_FLAG OR NOT CMAKE_SIZEOF_VOID_P EQUAL 8)
   set(ENABLE_LIBOMPTARGET OFF)
 endif()
 
@@ -100,6 +101,8 @@
     message(FATAL_ERROR "libomptarget cannot be built on Windows and MacOS X!")
   elseif (NOT OPENMP_HAVE_STD_CPP17_FLAG)
     message(FATAL_ERROR "Host compiler must support C++17 to build libomptarget!")
+  elseif (NOT CMAKE_SIZEOF_VOID_P EQUAL 8)
+    message(FATAL_ERROR "libomptarget on 32-bit systems are not supported!")
   endif()
 
   add_subdirectory(libomptarget)