diff --git a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
--- a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
@@ -4783,6 +4783,20 @@
                         Add, ConstantInt::get(A->getType(), C.shl(1)));
   }
 
+  // Canonicalize:
+  // Assume B_Pow2 != 0
+  // 1. A & B_Pow2 != B_Pow2 -> A & B_Pow2 == 0
+  // 2. A & B_Pow2 == B_Pow2 -> A & B_Pow2 != 0
+  if (match(Op0, m_c_And(m_Specific(Op1), m_Value())) &&
+      isKnownToBeAPowerOfTwo(Op1, /* orZero */ false, 0, &I))
+    return new ICmpInst(CmpInst::getInversePredicate(Pred), Op0,
+                        ConstantInt::getNullValue(Op0->getType()));
+
+  if (match(Op1, m_c_And(m_Specific(Op0), m_Value())) &&
+      isKnownToBeAPowerOfTwo(Op0, /* orZero */ false, 0, &I))
+    return new ICmpInst(CmpInst::getInversePredicate(Pred), Op1,
+                        ConstantInt::getNullValue(Op1->getType()));
+
   return nullptr;
 }
 
diff --git a/llvm/test/Transforms/InstCombine/icmp-and-shift.ll b/llvm/test/Transforms/InstCombine/icmp-and-shift.ll
--- a/llvm/test/Transforms/InstCombine/icmp-and-shift.ll
+++ b/llvm/test/Transforms/InstCombine/icmp-and-shift.ll
@@ -437,7 +437,7 @@
 ; CHECK-LABEL: @eq_and_shl_one(
 ; CHECK-NEXT:    [[POW2:%.*]] = shl nuw i8 1, [[Y:%.*]]
 ; CHECK-NEXT:    [[AND:%.*]] = and i8 [[POW2]], [[X:%.*]]
-; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i8 [[AND]], [[POW2]]
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ne i8 [[AND]], 0
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %pow2 = shl i8 1, %y
@@ -450,7 +450,7 @@
 ; CHECK-LABEL: @ne_and_shl_one_commute(
 ; CHECK-NEXT:    [[POW2:%.*]] = shl nuw <2 x i8> <i8 1, i8 poison>, [[Y:%.*]]
 ; CHECK-NEXT:    [[AND:%.*]] = and <2 x i8> [[POW2]], [[X:%.*]]
-; CHECK-NEXT:    [[CMP:%.*]] = icmp ne <2 x i8> [[POW2]], [[AND]]
+; CHECK-NEXT:    [[CMP:%.*]] = icmp eq <2 x i8> [[AND]], zeroinitializer
 ; CHECK-NEXT:    ret <2 x i1> [[CMP]]
 ;
   %pow2 = shl <2 x i8> <i8 1, i8 poison>, %y
@@ -464,7 +464,7 @@
 ; CHECK-NEXT:    [[X:%.*]] = mul i8 [[PX:%.*]], [[PX]]
 ; CHECK-NEXT:    [[POW2:%.*]] = lshr i8 -128, [[Y:%.*]]
 ; CHECK-NEXT:    [[AND:%.*]] = and i8 [[X]], [[POW2]]
-; CHECK-NEXT:    [[CMP:%.*]] = icmp ne i8 [[AND]], [[POW2]]
+; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i8 [[AND]], 0
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %x = mul i8 %px, %px ; thwart complexity-based canonicalization
@@ -481,7 +481,7 @@
 ; CHECK-NEXT:    call void @use(i8 [[POW2]])
 ; CHECK-NEXT:    [[AND:%.*]] = and i8 [[X]], [[POW2]]
 ; CHECK-NEXT:    call void @use(i8 [[AND]])
-; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i8 [[POW2]], [[AND]]
+; CHECK-NEXT:    [[CMP:%.*]] = icmp ne i8 [[AND]], 0
 ; CHECK-NEXT:    ret i1 [[CMP]]
 ;
   %x = mul i8 %px, %px ; thwart complexity-based canonicalization