diff --git a/lldb/cmake/modules/AddLLDB.cmake b/lldb/cmake/modules/AddLLDB.cmake
--- a/lldb/cmake/modules/AddLLDB.cmake
+++ b/lldb/cmake/modules/AddLLDB.cmake
@@ -243,6 +243,16 @@
     COMMAND ${CMAKE_COMMAND} -E copy $<TARGET_FILE:${name}> ${copy_dest}
     COMMENT "Copy ${name} to ${copy_dest}"
   )
+
+  # Create a custom target to remove the copy again from LLDB.framework in the
+  # build tree.
+  # Intentionally use remove_directory because the target can be a either a
+  # file or directory and using remove_directory is harmless for files.
+  add_custom_target(${name}-cleanup
+    COMMAND ${CMAKE_COMMAND} -E remove_directory ${copy_dest}
+    COMMENT "Removing ${name} from LLDB.framework")
+  add_dependencies(lldb-framework-cleanup
+    ${name}-cleanup)
 endfunction()
 
 # Add extra install steps for dSYM creation and stripping for the given target.
diff --git a/lldb/cmake/modules/LLDBConfig.cmake b/lldb/cmake/modules/LLDBConfig.cmake
--- a/lldb/cmake/modules/LLDBConfig.cmake
+++ b/lldb/cmake/modules/LLDBConfig.cmake
@@ -101,6 +101,20 @@
   # Essentially, emit the framework's dSYM outside of the framework directory.
   set(LLDB_DEBUGINFO_INSTALL_PREFIX ${CMAKE_BINARY_DIR}/${CMAKE_CFG_INTDIR}/bin CACHE STRING
       "Directory to emit dSYM files stripped from executables and libraries (Darwin Only)")
+
+  # Custom target to remove the targets (binaries, directories) that were
+  # copied into LLDB.framework in the build tree.
+  #
+  # These targets need to be removed before the install phase because otherwise
+  # because otherwise they may overwrite already installed binaries with the
+  # wrong RPATH (i.e. build RPATH instead of install RPATH).
+  #
+  # This target needs to be created here (rather than in API/CMakeLists.txt)
+  # because add_lldb_tool creates the custom rules to copy the binaries before
+  # the framework target exists and that's the only place where this is
+  # tracked.
+  add_custom_target(lldb-framework-cleanup
+    COMMENT "Cleaning up build-tree frameworks in preparation for install")
 endif()
 
 if(APPLE AND CMAKE_GENERATOR STREQUAL Xcode)
diff --git a/lldb/source/API/CMakeLists.txt b/lldb/source/API/CMakeLists.txt
--- a/lldb/source/API/CMakeLists.txt
+++ b/lldb/source/API/CMakeLists.txt
@@ -211,4 +211,9 @@
 
 if(LLDB_BUILD_FRAMEWORK)
   include(LLDBFramework)
+
+  add_dependencies(install-liblldb
+    lldb-framework-cleanup)
+  add_dependencies(install-liblldb-stripped
+    lldb-framework-cleanup)
 endif()