diff --git a/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp b/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
--- a/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
@@ -370,10 +370,12 @@
 // inttoptr ( ptrtoint (x) ) --> x
 Value *InstCombinerImpl::simplifyIntToPtrRoundTripCast(Value *Val) {
   auto *IntToPtr = dyn_cast<IntToPtrInst>(Val);
-  if (IntToPtr && DL.getPointerTypeSizeInBits(IntToPtr->getDestTy()) ==
-                      DL.getTypeSizeInBits(IntToPtr->getSrcTy())) {
+  if (!IntToPtr)
+    return nullptr;
+  Type *CastTy = IntToPtr->getDestTy();
+  if (!CastTy->isVectorTy() && DL.getPointerTypeSizeInBits(CastTy) ==
+                                   DL.getTypeSizeInBits(IntToPtr->getSrcTy())) {
     auto *PtrToInt = dyn_cast<PtrToIntInst>(IntToPtr->getOperand(0));
-    Type *CastTy = IntToPtr->getDestTy();
     if (PtrToInt &&
         CastTy->getPointerAddressSpace() ==
             PtrToInt->getSrcTy()->getPointerAddressSpace() &&