Index: llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
===================================================================
--- llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
+++ llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
@@ -3803,7 +3803,8 @@
   // poison.
   Use *MaybePoisonOperand = nullptr;
   for (Use &U : OrigOpInst->operands()) {
-    if (isGuaranteedNotToBeUndefOrPoison(U.get()))
+    if (isa<MetadataAsValue>(U.get()) ||
+        isGuaranteedNotToBeUndefOrPoison(U.get()))
       continue;
     if (!MaybePoisonOperand)
       MaybePoisonOperand = &U;
Index: llvm/test/Transforms/InstCombine/freeze-fp-ops.ll
===================================================================
--- llvm/test/Transforms/InstCombine/freeze-fp-ops.ll
+++ llvm/test/Transforms/InstCombine/freeze-fp-ops.ll
@@ -508,9 +508,9 @@
 
 define float @freeze_fptrunc_round(double %arg0) {
 ; CHECK-LABEL: @freeze_fptrunc_round(
-; CHECK-NEXT:    [[OP:%.*]] = call float @llvm.fptrunc.round.f32.f64(double [[ARG0:%.*]], metadata !"round.downward")
-; CHECK-NEXT:    [[FREEZE:%.*]] = freeze float [[OP]]
-; CHECK-NEXT:    ret float [[FREEZE]]
+; CHECK-NEXT:    [[ARG0_FR:%.*]] = freeze double [[ARG0:%.*]]
+; CHECK-NEXT:    [[OP:%.*]] = call float @llvm.fptrunc.round.f32.f64(double [[ARG0_FR]], metadata !"round.downward")
+; CHECK-NEXT:    ret float [[OP]]
 ;
   %op = call float @llvm.fptrunc.round.f32.f64(double %arg0, metadata !"round.downward")
   %freeze = freeze float %op