diff --git a/llvm/lib/CodeGen/PrologEpilogInserter.cpp b/llvm/lib/CodeGen/PrologEpilogInserter.cpp
--- a/llvm/lib/CodeGen/PrologEpilogInserter.cpp
+++ b/llvm/lib/CodeGen/PrologEpilogInserter.cpp
@@ -1234,6 +1234,9 @@
           if (!MO.isReg())
             continue;
 
+          if (MI.isDebugInstr())
+            continue;
+
           MCRegister Reg = MO.getReg();
           if (AllocatableSet[Reg] && !MO.isImplicit() &&
               (MO.isDef() || MO.isUse()))