Index: llvm/include/llvm/CodeGen/GlobalISel/CombinerHelper.h
===================================================================
--- llvm/include/llvm/CodeGen/GlobalISel/CombinerHelper.h
+++ llvm/include/llvm/CodeGen/GlobalISel/CombinerHelper.h
@@ -129,6 +129,10 @@
     return KB;
   }
 
+  MachineIRBuilder &getBuilder() const {
+    return Builder;
+  }
+
   const TargetLowering &getTargetLowering() const;
 
   /// \returns true if the combiner is running pre-legalization.
Index: llvm/include/llvm/Target/GlobalISel/Combine.td
===================================================================
--- llvm/include/llvm/Target/GlobalISel/Combine.td
+++ llvm/include/llvm/Target/GlobalISel/Combine.td
@@ -157,6 +157,22 @@
          [{ return Helper.matchSextInRegOfLoad(*${root}, ${matchinfo}); }]),
   (apply [{ Helper.applySextInRegOfLoad(*${root}, ${matchinfo}); }])>;
 
+def sext_inreg_to_zext_inreg : GICombineRule<
+  (defs root:$dst),
+  (match
+    (G_SEXT_INREG $dst, $src, $imm):$root,
+      [{
+        unsigned BitWidth = MRI.getType(${src}.getReg()).getScalarSizeInBits();
+        return Helper.getKnownBits()->maskedValueIsZero(${src}.getReg(),
+                 APInt::getOneBitSet(BitWidth, ${imm}.getImm() - 1)); }]),
+    (apply [{
+      Helper.getBuilder().setInstrAndDebugLoc(*${root});
+      Helper.getBuilder().buildZExtInReg(${dst}, ${src}, ${imm}.getImm());
+      ${root}->eraseFromParent();
+      return true;
+  }])
+>;
+
 def combine_indexed_load_store : GICombineRule<
   (defs root:$root, indexed_load_store_matchdata:$matchinfo),
   (match (wip_match_opcode G_LOAD, G_SEXTLOAD, G_ZEXTLOAD, G_STORE):$root,
@@ -1027,7 +1043,8 @@
 
 def known_bits_simplifications : GICombineGroup<[
   redundant_and, redundant_sext_inreg, redundant_or, urem_pow2_to_mask,
-  zext_trunc_fold, icmp_to_true_false_known_bits, icmp_to_lhs_known_bits]>;
+  zext_trunc_fold, icmp_to_true_false_known_bits, icmp_to_lhs_known_bits,
+  sext_inreg_to_zext_inreg]>;
 
 def width_reduction_combines : GICombineGroup<[reduce_shl_of_extend,
                                                narrow_binop_feeding_and]>;
Index: llvm/test/CodeGen/AMDGPU/GlobalISel/prelegalizer-combiner-sext_inreg-to-and.mir
===================================================================
--- /dev/null
+++ llvm/test/CodeGen/AMDGPU/GlobalISel/prelegalizer-combiner-sext_inreg-to-and.mir
@@ -0,0 +1,111 @@
+# NOTE: Assertions have been autogenerated by utils/update_mir_test_checks.py
+# RUN: llc -mtriple=amdgcn-amd-amdhsa -mcpu=gfx900 -run-pass=amdgpu-prelegalizer-combiner -verify-machineinstrs %s -o - | FileCheck %s
+
+---
+name:  sext_inreg_i32_8_and_neg255
+legalized:       true
+tracksRegLiveness: true
+body:             |
+  bb.0:
+    liveins: $vgpr0_vgpr1
+
+    ; CHECK-LABEL: name: sext_inreg_i32_8_and_neg255
+    ; CHECK: liveins: $vgpr0_vgpr1
+    ; CHECK-NEXT: {{  $}}
+    ; CHECK-NEXT: %ptr:_(p1) = COPY $vgpr0_vgpr1
+    ; CHECK-NEXT: %load:_(s32) = G_LOAD %ptr(p1) :: (volatile load (s32), addrspace 1)
+    ; CHECK-NEXT: [[C:%[0-9]+]]:_(s32) = G_CONSTANT i32 1
+    ; CHECK-NEXT: %inreg:_(s32) = G_AND %load, [[C]]
+    ; CHECK-NEXT: $vgpr0 = COPY %inreg(s32)
+    %ptr:_(p1) = COPY $vgpr0_vgpr1
+    %load:_(s32) = G_LOAD %ptr :: (volatile load (s32), addrspace 1, align 4)
+    %mask:_(s32) = G_CONSTANT i32 -255
+    %and:_(s32) = G_AND %load, %mask
+    %inreg:_(s32) = G_SEXT_INREG %and, 8
+    $vgpr0 = COPY %inreg
+
+...
+
+---
+name:  sext_inreg_i32_8_and_255
+legalized:       true
+tracksRegLiveness: true
+body:             |
+  bb.0:
+    liveins: $vgpr0_vgpr1
+
+    ; CHECK-LABEL: name: sext_inreg_i32_8_and_255
+    ; CHECK: liveins: $vgpr0_vgpr1
+    ; CHECK-NEXT: {{  $}}
+    ; CHECK-NEXT: %ptr:_(p1) = COPY $vgpr0_vgpr1
+    ; CHECK-NEXT: %load:_(s32) = G_LOAD %ptr(p1) :: (volatile load (s32), addrspace 1)
+    ; CHECK-NEXT: %mask:_(s32) = G_CONSTANT i32 255
+    ; CHECK-NEXT: %and:_(s32) = G_AND %load, %mask
+    ; CHECK-NEXT: %inreg:_(s32) = G_SEXT_INREG %and, 8
+    ; CHECK-NEXT: $vgpr0 = COPY %inreg(s32)
+    %ptr:_(p1) = COPY $vgpr0_vgpr1
+    %load:_(s32) = G_LOAD %ptr :: (volatile load (s32), addrspace 1, align 4)
+    %mask:_(s32) = G_CONSTANT i32 255
+    %and:_(s32) = G_AND %load, %mask
+    %inreg:_(s32) = G_SEXT_INREG %and, 8
+    $vgpr0 = COPY %inreg
+
+...
+
+---
+name:  sext_inreg_v2i32_8_and_neg255
+legalized:       true
+tracksRegLiveness: true
+body:             |
+  bb.0:
+    liveins: $vgpr0_vgpr1
+
+    ; CHECK-LABEL: name: sext_inreg_v2i32_8_and_neg255
+    ; CHECK: liveins: $vgpr0_vgpr1
+    ; CHECK-NEXT: {{  $}}
+    ; CHECK-NEXT: %ptr:_(p1) = COPY $vgpr0_vgpr1
+    ; CHECK-NEXT: %load:_(<2 x s32>) = G_LOAD %ptr(p1) :: (volatile load (<2 x s32>), addrspace 1)
+    ; CHECK-NEXT: %mask_elt:_(s32) = G_CONSTANT i32 -255
+    ; CHECK-NEXT: %mask:_(<2 x s32>) = G_BUILD_VECTOR %mask_elt(s32), %mask_elt(s32)
+    ; CHECK-NEXT: %and:_(<2 x s32>) = G_AND %load, %mask
+    ; CHECK-NEXT: [[C:%[0-9]+]]:_(s32) = G_CONSTANT i32 255
+    ; CHECK-NEXT: [[BUILD_VECTOR:%[0-9]+]]:_(<2 x s32>) = G_BUILD_VECTOR [[C]](s32), [[C]](s32)
+    ; CHECK-NEXT: %inreg:_(<2 x s32>) = G_AND %and, [[BUILD_VECTOR]]
+    ; CHECK-NEXT: $vgpr0_vgpr1 = COPY %inreg(<2 x s32>)
+    %ptr:_(p1) = COPY $vgpr0_vgpr1
+    %load:_(<2 x s32>) = G_LOAD %ptr :: (volatile load (<2 x s32>), addrspace 1, align 8)
+    %mask_elt:_(s32) = G_CONSTANT i32 -255
+    %mask:_(<2 x s32>) = G_BUILD_VECTOR %mask_elt, %mask_elt
+    %and:_(<2 x s32>) = G_AND %load, %mask
+    %inreg:_(<2 x s32>) = G_SEXT_INREG %and, 8
+    $vgpr0_vgpr1 = COPY %inreg
+
+...
+
+---
+name:  sext_inreg_v2i32_8_and_255
+legalized:       true
+tracksRegLiveness: true
+body:             |
+  bb.0:
+    liveins: $vgpr0_vgpr1
+
+    ; CHECK-LABEL: name: sext_inreg_v2i32_8_and_255
+    ; CHECK: liveins: $vgpr0_vgpr1
+    ; CHECK-NEXT: {{  $}}
+    ; CHECK-NEXT: %ptr:_(p1) = COPY $vgpr0_vgpr1
+    ; CHECK-NEXT: %load:_(<2 x s32>) = G_LOAD %ptr(p1) :: (volatile load (<2 x s32>), addrspace 1)
+    ; CHECK-NEXT: %mask_elt:_(s32) = G_CONSTANT i32 255
+    ; CHECK-NEXT: %mask:_(<2 x s32>) = G_BUILD_VECTOR %mask_elt(s32), %mask_elt(s32)
+    ; CHECK-NEXT: %and:_(<2 x s32>) = G_AND %load, %mask
+    ; CHECK-NEXT: %inreg:_(<2 x s32>) = G_SEXT_INREG %and, 8
+    ; CHECK-NEXT: $vgpr0_vgpr1 = COPY %inreg(<2 x s32>)
+    %ptr:_(p1) = COPY $vgpr0_vgpr1
+    %load:_(<2 x s32>) = G_LOAD %ptr :: (volatile load (<2 x s32>), addrspace 1, align 8)
+    %mask_elt:_(s32) = G_CONSTANT i32 255
+    %mask:_(<2 x s32>) = G_BUILD_VECTOR %mask_elt, %mask_elt
+    %and:_(<2 x s32>) = G_AND %load, %mask
+    %inreg:_(<2 x s32>) = G_SEXT_INREG %and, 8
+    $vgpr0_vgpr1 = COPY %inreg
+
+...