diff --git a/llvm/lib/Target/AMDGPU/VINTERPInstructions.td b/llvm/lib/Target/AMDGPU/VINTERPInstructions.td
--- a/llvm/lib/Target/AMDGPU/VINTERPInstructions.td
+++ b/llvm/lib/Target/AMDGPU/VINTERPInstructions.td
@@ -63,6 +63,10 @@
   let HasOpSel = 0;
   let HasModifiers = 1;
 
+  let Src0Mod = FPVRegInputMods;
+  let Src1Mod = FPVRegInputMods;
+  let Src2Mod = FPVRegInputMods;
+
   let Outs64 = (outs VGPR_32:$vdst);
   let Ins64 = (ins Src0Mod:$src0_modifiers, VRegSrc_32:$src0,
                    Src1Mod:$src1_modifiers, VRegSrc_32:$src1,
@@ -77,6 +81,10 @@
   let HasOpSel = 1;
   let HasModifiers = 1;
 
+  let Src0Mod = FPVRegInputMods;
+  let Src1Mod = FPVRegInputMods;
+  let Src2Mod = FPVRegInputMods;
+
   let Outs64 = (outs VGPR_32:$vdst);
   let Ins64 = (ins Src0Mod:$src0_modifiers, VRegSrc_32:$src0,
                    Src1Mod:$src1_modifiers, VRegSrc_32:$src1,
diff --git a/llvm/test/MC/AMDGPU/gfx11_asm_vinterp_err.s b/llvm/test/MC/AMDGPU/gfx11_asm_vinterp_err.s
new file mode 100644
--- /dev/null
+++ b/llvm/test/MC/AMDGPU/gfx11_asm_vinterp_err.s
@@ -0,0 +1,42 @@
+// RUN: not llvm-mc -arch=amdgcn -mcpu=gfx1100 %s 2>&1 | FileCheck %s -check-prefix=GFX11-ERR --implicit-check-not=error: --strict-whitespace
+
+//===----------------------------------------------------------------------===//
+// VINTERP src operands must be VGPRs.
+// Check that other operand kinds are rejected by assembler.
+//===----------------------------------------------------------------------===//
+
+v_interp_p10_f32 v0, s1, v2, v3
+// GFX11-ERR: error: invalid operand for instruction
+
+v_interp_p10_f32 v0, v1, s2, v3
+// GFX11-ERR: error: invalid operand for instruction
+
+v_interp_p10_f32 v0, v1, v2, s3
+// GFX11-ERR: error: invalid operand for instruction
+
+v_interp_p2_f32 v0, 1, v2, v3
+// GFX11-ERR: error: invalid operand for instruction
+
+v_interp_p2_f32 v0, v1, 2, v3
+// GFX11-ERR: error: invalid operand for instruction
+
+v_interp_p2_f32 v0, v1, v2, 3
+// GFX11-ERR: error: invalid operand for instruction
+
+v_interp_p10_f16_f32 v0, s1, v2, v3
+// GFX11-ERR: error: invalid operand for instruction
+
+v_interp_p10_f16_f32 v0, v1, s2, v3
+// GFX11-ERR: error: invalid operand for instruction
+
+v_interp_p10_f16_f32 v0, v1, v2, s3
+// GFX11-ERR: error: invalid operand for instruction
+
+v_interp_p2_f16_f32 v0, 1, v2, v3
+// GFX11-ERR: error: invalid operand for instruction
+
+v_interp_p2_f16_f32 v0, v1, 2, v3
+// GFX11-ERR: error: invalid operand for instruction
+
+v_interp_p2_f16_f32 v0, v1, v2, 3
+// GFX11-ERR: error: invalid operand for instruction