diff --git a/clang/CMakeLists.txt b/clang/CMakeLists.txt
--- a/clang/CMakeLists.txt
+++ b/clang/CMakeLists.txt
@@ -868,7 +868,7 @@
   endforeach()
 endif()
 
-if (CLANG_BOLT_INSTRUMENT)
+if (CLANG_BOLT_INSTRUMENT AND NOT LLVM_BUILD_INSTRUMENTED)
   set(CLANG_PATH ${LLVM_RUNTIME_OUTPUT_INTDIR}/clang)
   set(CLANGXX_PATH ${CLANG_PATH}++)
   set(CLANG_INSTRUMENTED ${CLANG_PATH}-bolt.inst)
diff --git a/clang/cmake/caches/BOLT-PGO.cmake b/clang/cmake/caches/BOLT-PGO.cmake
new file mode 100644
--- /dev/null
+++ b/clang/cmake/caches/BOLT-PGO.cmake
@@ -0,0 +1,11 @@
+set(LLVM_ENABLE_PROJECTS "bolt;clang;lld" CACHE STRING "")
+
+set(CLANG_BOOTSTRAP_TARGETS
+  stage2-clang++-bolt
+  CACHE STRING "")
+set(BOOTSTRAP_CLANG_BOOTSTRAP_TARGETS
+  clang++-bolt
+  CACHE STRING "")
+
+set(PGO_BUILD_CONFIGURATION ${CMAKE_CURRENT_LIST_DIR}/BOLT.cmake CACHE STRING "")
+include(${CMAKE_CURRENT_LIST_DIR}/PGO.cmake)