diff --git a/llvm/lib/Target/NVPTX/NVPTXISelLowering.cpp b/llvm/lib/Target/NVPTX/NVPTXISelLowering.cpp
--- a/llvm/lib/Target/NVPTX/NVPTXISelLowering.cpp
+++ b/llvm/lib/Target/NVPTX/NVPTXISelLowering.cpp
@@ -564,9 +564,13 @@
     setFP16OperationAction(Op, MVT::v2f16, Legal, Expand);
   }
 
-  // There's no neg.f16 instruction. Expand to (0-x).
-  setOperationAction(ISD::FNEG, MVT::f16, Expand);
-  setOperationAction(ISD::FNEG, MVT::v2f16, Expand);
+  // f16/f16x2 neg was introduced in PTX 60, SM_53.
+  const bool IsFP16FP16x2NegAvailable = STI.getSmVersion() >= 53 &&
+                                        STI.getPTXVersion() >= 60 &&
+                                        STI.allowFP16Math();
+  for (const auto &VT : {MVT::f16, MVT::v2f16})
+    setOperationAction(ISD::FNEG, VT,
+                       IsFP16FP16x2NegAvailable ? Legal : Expand);
 
   // (would be) Library functions.
 
diff --git a/llvm/lib/Target/NVPTX/NVPTXInstrInfo.td b/llvm/lib/Target/NVPTX/NVPTXInstrInfo.td
--- a/llvm/lib/Target/NVPTX/NVPTXInstrInfo.td
+++ b/llvm/lib/Target/NVPTX/NVPTXInstrInfo.td
@@ -921,6 +921,19 @@
 defm FNEG  : F2<"neg", fneg>;
 defm FSQRT : F2<"sqrt.rn", fsqrt>;
 
+//
+// F16 NEG
+//
+class FNEG_F16_F16X2<string OpcStr, RegisterClass RC, Predicate Pred> :
+      NVPTXInst<(outs RC:$dst), (ins RC:$src),
+                !strconcat(OpcStr, " \t$dst, $src;"),
+                [(set RC:$dst, (fneg RC:$src))]>,
+                Requires<[useFP16Math, hasPTX60, hasSM53, Pred]>;
+def FNEG16_ftz   : FNEG_F16_F16X2<"neg.ftz.f16", Float16Regs, doF32FTZ>;
+def FNEG16       : FNEG_F16_F16X2<"neg.f16", Float16Regs, True>;
+def FNEG16x2_ftz : FNEG_F16_F16X2<"neg.ftz.f16x2", Float16x2Regs, doF32FTZ>;
+def FNEG16x2     : FNEG_F16_F16X2<"neg.f16x2", Float16x2Regs, True>;
+
 //
 // F64 division
 //
diff --git a/llvm/test/CodeGen/NVPTX/f16-instructions.ll b/llvm/test/CodeGen/NVPTX/f16-instructions.ll
--- a/llvm/test/CodeGen/NVPTX/f16-instructions.ll
+++ b/llvm/test/CodeGen/NVPTX/f16-instructions.ll
@@ -1,27 +1,29 @@
 ; ## Full FP16 support enabled by default.
 ; RUN: llc < %s -mtriple=nvptx64-nvidia-cuda -mcpu=sm_53 -asm-verbose=false \
 ; RUN:          -O0 -disable-post-ra -frame-pointer=all -verify-machineinstrs \
+; RUN:          -mattr=+ptx60                                                 \
 ; RUN: | FileCheck -check-prefixes CHECK,CHECK-NOFTZ,CHECK-F16-NOFTZ %s
 ; RUN: %if ptxas %{                                                           \
 ; RUN:   llc < %s -mtriple=nvptx64-nvidia-cuda -mcpu=sm_53 -asm-verbose=false \
 ; RUN:          -O0 -disable-post-ra -frame-pointer=all -verify-machineinstrs \
+; RUN:          -mattr=+ptx60                                                 \
 ; RUN:   | %ptxas-verify -arch=sm_53                                          \
 ; RUN: %}
 ; ## Full FP16 with FTZ
 ; RUN: llc < %s -mtriple=nvptx64-nvidia-cuda -mcpu=sm_53 -asm-verbose=false \
 ; RUN:          -O0 -disable-post-ra -frame-pointer=all -verify-machineinstrs \
-; RUN:          -denormal-fp-math-f32=preserve-sign \
+; RUN:          -denormal-fp-math-f32=preserve-sign -mattr=+ptx60             \
 ; RUN: | FileCheck -check-prefixes CHECK,CHECK-F16-FTZ %s
 ; RUN: %if ptxas %{                                                           \
 ; RUN:   llc < %s -mtriple=nvptx64-nvidia-cuda -mcpu=sm_53 -asm-verbose=false \
 ; RUN:          -O0 -disable-post-ra -frame-pointer=all -verify-machineinstrs \
-; RUN:          -denormal-fp-math-f32=preserve-sign                           \
+; RUN:          -denormal-fp-math-f32=preserve-sign -mattr=+ptx60             \
 ; RUN:   | %ptxas-verify -arch=sm_53                                          \
 ; RUN: %}
 ; ## FP16 support explicitly disabled.
 ; RUN: llc < %s -mtriple=nvptx64-nvidia-cuda -mcpu=sm_53 -asm-verbose=false \
 ; RUN:          -O0 -disable-post-ra -frame-pointer=all --nvptx-no-f16-math \
-; RUN:           -verify-machineinstrs \
+; RUN:          -verify-machineinstrs -mattr=+ptx60                         \
 ; RUN: | FileCheck -check-prefixes CHECK,CHECK-NOFTZ,CHECK-NOF16 %s
 ; RUN: %if ptxas %{                                                           \
 ; RUN:   llc < %s -mtriple=nvptx64-nvidia-cuda -mcpu=sm_53 -asm-verbose=false \
@@ -1168,5 +1170,24 @@
   ret half %r
 }
 
+; CHECK-LABEL: test_neg_f16(
+; CHECK-F16-NOFTZ: neg.f16
+; CHECK-F16-FTZ: neg.ftz.f16
+; CHECK-NOF16: xor.b16  	%rs{{.*}}, %rs{{.*}}, -32768
+define half @test_neg_f16(half noundef %arg) #0 {
+  %res = fneg half %arg
+  ret half %res
+}
+
+; CHECK-LABEL: test_neg_f16x2(
+; CHECK-F16-NOFTZ: neg.f16x2
+; CHECK-F16-FTZ: neg.ftz.f16x2
+; CHECK-NOF16: xor.b16  	%rs{{.*}}, %rs{{.*}}, -32768
+; CHECK-NOF16: xor.b16  	%rs{{.*}}, %rs{{.*}}, -32768
+define <2 x half> @test_neg_f16x2(<2 x half> noundef %arg) #0 {
+  %res = fneg <2 x half> %arg
+  ret <2 x half> %res
+}
+
 attributes #0 = { nounwind }
 attributes #1 = { "unsafe-fp-math" = "true" }