diff --git a/llvm/lib/IR/DebugInfo.cpp b/llvm/lib/IR/DebugInfo.cpp
--- a/llvm/lib/IR/DebugInfo.cpp
+++ b/llvm/lib/IR/DebugInfo.cpp
@@ -823,7 +823,14 @@
 
   // If this isn't a call, drop the location to allow a location from a
   // preceding instruction to propagate.
-  if (!isa<CallBase>(this)) {
+  bool MayLowerToCall = false;
+  if (isa<CallBase>(this)) {
+    auto *II = dyn_cast<IntrinsicInst>(this);
+    MayLowerToCall =
+        !II || IntrinsicInst::mayLowerToFunctionCall(II->getIntrinsicID());
+  }
+
+  if (!MayLowerToCall) {
     setDebugLoc(DebugLoc());
     return;
   }
diff --git a/llvm/test/DebugInfo/Generic/licm-hoist-intrinsic-debug-loc.ll b/llvm/test/DebugInfo/Generic/licm-hoist-intrinsic-debug-loc.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/DebugInfo/Generic/licm-hoist-intrinsic-debug-loc.ll
@@ -0,0 +1,46 @@
+; RUN: opt -S -licm %s | FileCheck %s
+;
+; LICM should null out debug locations when it hoists intrinsics that won't lower to function calls out of a loop.
+; CHECK: define float @foo
+; CHECK-NEXT: entry:
+; CHECK-NEXT: call float @llvm.fma.f32(float %coef_0, float %coef_1, float 0.000000e+00){{$}}
+; CHECK-NEXT: br label %loop.header
+;
+define float @foo(float* %A, float %coef_0, float %coef_1, i32 %n) !dbg !2 {
+entry:
+  br label %loop.header
+
+loop.header:
+  %i = phi i32 [ 0, %entry ], [ %i.inc, %loop.backedge ]
+  %a = phi float [ 0.000000e+00, %entry ], [ %a.inc, %loop.backedge ]
+  %cond = icmp ult i32 %i, %n
+  br i1 %cond, label %loop.backedge, label %exit
+
+loop.backedge:
+  %i.cast = zext i32 %i to i64
+  %A.ptr = getelementptr inbounds float, float* %A, i64 %i.cast
+  %A.load = load float, float* %A.ptr
+  %fma = call float @llvm.fma.f32(float %coef_0, float %coef_1, float 0.000000e+00), !dbg !3
+  %mul = fmul float %fma, %A.load
+  %a.inc = fadd float %mul, %a
+  %i.inc = add i32 %i, 1
+  br label %loop.header
+
+exit:
+  ret float %a
+}
+
+declare float @llvm.fma.f32(float, float, float) #1
+
+attributes #0 = { nofree nosync nounwind readnone speculatable willreturn }
+
+!llvm.dbg.cu = !{!0}
+!llvm.module.flags = !{!6}
+
+!0 = distinct !DICompileUnit(language: DW_LANG_C99, file: !1, producer: "clang version 14", isOptimized: false, runtimeVersion: 0, emissionKind: LineTablesOnly, splitDebugInlining: false, nameTableKind: None)
+!1 = !DIFile(filename: "source.c", directory: "/")
+!2 = distinct !DISubprogram(name: "foo", scope: !1, file: !1, line: 1, type: !4, scopeLine: 1, flags: DIFlagPrototyped, spFlags: DISPFlagDefinition, unit: !0, retainedNodes: !5)
+!3 = !DILocation(line: 4, column: 17, scope: !2)
+!4 = !DISubroutineType(types: !5)
+!5 = !{}
+!6 = !{i32 2, !"Debug Info Version", i32 3}
\ No newline at end of file