diff --git a/clang/include/clang/Basic/Module.h b/clang/include/clang/Basic/Module.h
--- a/clang/include/clang/Basic/Module.h
+++ b/clang/include/clang/Basic/Module.h
@@ -608,8 +608,7 @@
 
   /// Set the serialized AST file for the top-level module of this module.
   void setASTFile(Optional<FileEntryRef> File) {
-    assert((!File || !getASTFile() || getASTFile() == File) &&
-           "file path changed");
+    assert((!getASTFile() || getASTFile() == File) && "file path changed");
     getTopLevelModule()->ASTFile = File;
   }
 
diff --git a/clang/include/clang/Serialization/ModuleManager.h b/clang/include/clang/Serialization/ModuleManager.h
--- a/clang/include/clang/Serialization/ModuleManager.h
+++ b/clang/include/clang/Serialization/ModuleManager.h
@@ -250,7 +250,7 @@
                             std::string &ErrorStr);
 
   /// Remove the modules starting from First (to the end).
-  void removeModules(ModuleIterator First, ModuleMap *modMap);
+  void removeModules(ModuleIterator First);
 
   /// Add an in-memory buffer the list of known buffers
   void addInMemoryBuffer(StringRef FileName,
diff --git a/clang/lib/Serialization/ASTReader.cpp b/clang/lib/Serialization/ASTReader.cpp
--- a/clang/lib/Serialization/ASTReader.cpp
+++ b/clang/lib/Serialization/ASTReader.cpp
@@ -4227,10 +4227,7 @@
           ReadASTCore(FileName, Type, ImportLoc,
                       /*ImportedBy=*/nullptr, Loaded, 0, 0, ASTFileSignature(),
                       ClientLoadCapabilities)) {
-    ModuleMgr.removeModules(ModuleMgr.begin() + NumModules,
-                            PP.getLangOpts().Modules
-                                ? &PP.getHeaderSearchInfo().getModuleMap()
-                                : nullptr);
+    ModuleMgr.removeModules(ModuleMgr.begin() + NumModules);
 
     // If we find that any modules are unusable, the global index is going
     // to be out-of-date. Just remove it.
diff --git a/clang/lib/Serialization/ModuleManager.cpp b/clang/lib/Serialization/ModuleManager.cpp
--- a/clang/lib/Serialization/ModuleManager.cpp
+++ b/clang/lib/Serialization/ModuleManager.cpp
@@ -249,7 +249,7 @@
   return NewlyLoaded;
 }
 
-void ModuleManager::removeModules(ModuleIterator First, ModuleMap *modMap) {
+void ModuleManager::removeModules(ModuleIterator First) {
   auto Last = end();
   if (First == Last)
     return;
@@ -280,19 +280,11 @@
     }
   }
 
-  // Delete the modules and erase them from the various structures.
+  // Delete the modules.
   for (ModuleIterator victim = First; victim != Last; ++victim) {
     Modules.erase(victim->File);
-
-    if (modMap) {
-      StringRef ModuleName = victim->ModuleName;
-      if (Module *mod = modMap->findModule(ModuleName)) {
-        mod->setASTFile(None);
-      }
-    }
   }
 
-  // Delete the modules.
   Chain.erase(Chain.begin() + (First - begin()), Chain.end());
 }
 
diff --git a/clang/test/Modules/dependent-module-different-location.m b/clang/test/Modules/dependent-module-different-location.m
new file mode 100644
--- /dev/null
+++ b/clang/test/Modules/dependent-module-different-location.m
@@ -0,0 +1,44 @@
+// RUN: rm -rf %t
+// RUN: split-file %s %t
+//
+// At first build Stable.pcm that references Movable.framework from StableFrameworks.
+// RUN: %clang_cc1 -fsyntax-only -F %t/JustBuilt -F %t/StableFrameworks %t/prepopulate-module-cache.m \
+// RUN:            -fmodules -fimplicit-module-maps -fmodules-cache-path=%t/modules.cache
+//
+// Now add Movable.framework to JustBuilt.
+// RUN: mkdir %t/JustBuilt
+// RUN: cp -r %t/StableFrameworks/Movable.framework %t/JustBuilt/Movable.framework
+//
+// Load Movable.pcm at first for JustBuilt location and then in the same TU try to load transitively for StableFrameworks location.
+// RUN: %clang_cc1 -fsyntax-only -F %t/JustBuilt -F %t/StableFrameworks %t/trigger-error.m \
+// RUN:            -fmodules -fimplicit-module-maps -fmodules-cache-path=%t/modules.cache
+
+// Test the case when a dependent module is found in a different location, so
+// module cache has outdated information. <rdar://97216258>
+
+//--- StableFrameworks/Movable.framework/Headers/Movable.h
+// empty
+
+//--- StableFrameworks/Movable.framework/Modules/module.modulemap
+framework module Movable {
+  header "Movable.h"
+  export *
+}
+
+
+//--- StableFrameworks/Stable.framework/Headers/Stable.h
+#import <Movable/Movable.h>
+
+//--- StableFrameworks/Stable.framework/Modules/module.modulemap
+framework module Stable {
+  header "Stable.h"
+  export *
+}
+
+
+//--- prepopulate-module-cache.m
+#import <Stable/Stable.h>
+
+//--- trigger-error.m
+#import <Movable/Movable.h>
+#import <Stable/Stable.h>