diff --git a/clang/lib/CodeGen/CGHLSLRuntime.cpp b/clang/lib/CodeGen/CGHLSLRuntime.cpp
--- a/clang/lib/CodeGen/CGHLSLRuntime.cpp
+++ b/clang/lib/CodeGen/CGHLSLRuntime.cpp
@@ -212,4 +212,14 @@
     for (auto *Fn : DtorFns)
       B.CreateCall(FunctionCallee(Fn));
   }
+
+  // No need to keep global ctors/dtors for non-lib profile after call to
+  // ctors/dtors added for entry.
+  Triple T(M.getTargetTriple());
+  if (T.getEnvironment() != Triple::EnvironmentType::Library) {
+    if (auto *GV = M.getNamedGlobal("llvm.global_ctors"))
+      GV->eraseFromParent();
+    if (auto *GV = M.getNamedGlobal("llvm.global_dtors"))
+      GV->eraseFromParent();
+  }
 }
diff --git a/clang/test/CodeGenHLSL/GlobalConstructorFunction.hlsl b/clang/test/CodeGenHLSL/GlobalConstructorFunction.hlsl
--- a/clang/test/CodeGenHLSL/GlobalConstructorFunction.hlsl
+++ b/clang/test/CodeGenHLSL/GlobalConstructorFunction.hlsl
@@ -17,6 +17,10 @@
 [numthreads(1,1,1)]
 void main(unsigned GI : SV_GroupIndex) {}
 
+// Make sure global variable for ctors/dtors removed.
+// CHECK-NOT:@llvm.global_ctors
+// CHECK-NOT:@llvm.global_dtors
+
 //CHECK: define void @main()
 //CHECK-NEXT: entry:
 //CHECK-NEXT:   call void @"?call_me_first@@YAXXZ"()
diff --git a/clang/test/CodeGenHLSL/GlobalConstructorLib.hlsl b/clang/test/CodeGenHLSL/GlobalConstructorLib.hlsl
--- a/clang/test/CodeGenHLSL/GlobalConstructorLib.hlsl
+++ b/clang/test/CodeGenHLSL/GlobalConstructorLib.hlsl
@@ -1,5 +1,8 @@
 // RUN: %clang_cc1 -triple dxil-pc-shadermodel6.3-library -S -emit-llvm -disable-llvm-passes %s -o - | FileCheck %s
 
+// Make sure global variable for ctors exist for lib profile.
+// CHECK:@llvm.global_ctors
+
 RWBuffer<float> Buffer;
 
 [shader("compute")]
diff --git a/clang/test/CodeGenHLSL/GlobalConstructors.hlsl b/clang/test/CodeGenHLSL/GlobalConstructors.hlsl
--- a/clang/test/CodeGenHLSL/GlobalConstructors.hlsl
+++ b/clang/test/CodeGenHLSL/GlobalConstructors.hlsl
@@ -5,6 +5,9 @@
 [numthreads(1,1,1)]
 void main(unsigned GI : SV_GroupIndex) {}
 
+// Make sure global variable for ctors/dtors removed.
+// CHECK-NOT:@llvm.global_ctors
+// CHECK-NOT:@llvm.global_dtors
 //CHECK:      define void @main()
 //CHECK-NEXT: entry:
 //CHECK-NEXT:   call void @_GLOBAL__sub_I_GlobalConstructors.hlsl()
diff --git a/clang/test/CodeGenHLSL/GlobalDestructors.hlsl b/clang/test/CodeGenHLSL/GlobalDestructors.hlsl
--- a/clang/test/CodeGenHLSL/GlobalDestructors.hlsl
+++ b/clang/test/CodeGenHLSL/GlobalDestructors.hlsl
@@ -1,5 +1,10 @@
-// RUN: %clang_cc1 -triple dxil-pc-shadermodel6.0-compute -std=hlsl202x -S -emit-llvm -disable-llvm-passes %s -o - | FileCheck %s
-// RUN: %clang_cc1 -triple dxil-pc-shadermodel6.3-library -std=hlsl202x -S -emit-llvm -disable-llvm-passes %s -o - | FileCheck %s --check-prefixes=CHECK
+// RUN: %clang_cc1 -triple dxil-pc-shadermodel6.0-compute -std=hlsl202x -S -emit-llvm -disable-llvm-passes %s -o - | FileCheck %s --check-prefixes=CS,CHECK
+// RUN: %clang_cc1 -triple dxil-pc-shadermodel6.3-library -std=hlsl202x -S -emit-llvm -disable-llvm-passes %s -o - | FileCheck %s --check-prefixes=LIB,CHECK
+
+// Make sure global variable for dtors exist for lib profile.
+// LIB:@llvm.global_dtors
+// Make sure global variable for dtors removed for compute profile.
+// CS-NOT:llvm.global_dtors
 
 struct Tail {
   Tail() {
@@ -40,6 +45,9 @@
   Wag();
 }
 
+// Make sure global variable for ctors/dtors removed.
+// CHECK-NOT:@llvm.global_ctors
+// CHECK-NOT:@llvm.global_dtors
 //CHECK:      define void @main()
 //CHECK-NEXT: entry:
 //CHECK-NEXT:   call void @_GLOBAL__sub_I_GlobalDestructors.hlsl()