diff --git a/clang/lib/CodeGen/CodeGenModule.cpp b/clang/lib/CodeGen/CodeGenModule.cpp
--- a/clang/lib/CodeGen/CodeGenModule.cpp
+++ b/clang/lib/CodeGen/CodeGenModule.cpp
@@ -182,15 +182,11 @@
   if (CodeGenOpts.hasProfileClangUse()) {
     auto ReaderOrErr = llvm::IndexedInstrProfReader::create(
         CodeGenOpts.ProfileInstrumentUsePath, CodeGenOpts.ProfileRemappingFile);
-    if (auto E = ReaderOrErr.takeError()) {
-      unsigned DiagID = Diags.getCustomDiagID(DiagnosticsEngine::Error,
-                                              "Could not read profile %0: %1");
-      llvm::handleAllErrors(std::move(E), [&](const llvm::ErrorInfoBase &EI) {
-        getDiags().Report(DiagID) << CodeGenOpts.ProfileInstrumentUsePath
-                                  << EI.message();
-      });
-    } else
-      PGOReader = std::move(ReaderOrErr.get());
+    // We're checking for profile read errors in CompilerInvocation, so if
+    // there was an error it should've already been caught. If it hasn't been
+    // somehow, trip an assertion.
+    assert(ReaderOrErr);
+    PGOReader = std::move(ReaderOrErr.get());
   }
 
   // If coverage mapping generation is enabled, create the
diff --git a/clang/lib/Frontend/CompilerInvocation.cpp b/clang/lib/Frontend/CompilerInvocation.cpp
--- a/clang/lib/Frontend/CompilerInvocation.cpp
+++ b/clang/lib/Frontend/CompilerInvocation.cpp
@@ -1293,12 +1293,15 @@
 
 // Set the profile kind using fprofile-instrument-use-path.
 static void setPGOUseInstrumentor(CodeGenOptions &Opts,
-                                  const Twine &ProfileName) {
+                                  const Twine &ProfileName,
+                                  DiagnosticsEngine &Diags) {
   auto ReaderOrErr = llvm::IndexedInstrProfReader::create(ProfileName);
-  // In error, return silently and let Clang PGOUse report the error message.
   if (auto E = ReaderOrErr.takeError()) {
-    llvm::consumeError(std::move(E));
-    Opts.setProfileUse(CodeGenOptions::ProfileClangInstr);
+    unsigned DiagID = Diags.getCustomDiagID(DiagnosticsEngine::Error,
+                                            "Error in reading profile %0: %1");
+    llvm::handleAllErrors(std::move(E), [&](const llvm::ErrorInfoBase &EI) {
+      Diags.Report(DiagID) << ProfileName.str() << EI.message();
+    });
     return;
   }
   std::unique_ptr<llvm::IndexedInstrProfReader> PGOReader =
@@ -1717,7 +1720,7 @@
   }
 
   if (!Opts.ProfileInstrumentUsePath.empty())
-    setPGOUseInstrumentor(Opts, Opts.ProfileInstrumentUsePath);
+    setPGOUseInstrumentor(Opts, Opts.ProfileInstrumentUsePath, Diags);
 
   if (const Arg *A = Args.getLastArg(OPT_ftime_report, OPT_ftime_report_EQ)) {
     Opts.TimePasses = true;
diff --git a/clang/test/Profile/profile-does-not-exist-ir.c b/clang/test/Profile/profile-does-not-exist-ir.c
new file mode 100644
--- /dev/null
+++ b/clang/test/Profile/profile-does-not-exist-ir.c
@@ -0,0 +1,4 @@
+// RUN: not %clang_cc1 -emit-llvm -x ir %s -o - -fprofile-instrument-use-path=%t.nonexistent.profdata 2>&1 | FileCheck %s
+
+// CHECK: error: Error in reading profile {{.*}}.nonexistent.profdata:
+// CHECK-NOT: Assertion failed
diff --git a/clang/test/Profile/profile-does-not-exist.c b/clang/test/Profile/profile-does-not-exist.c
--- a/clang/test/Profile/profile-does-not-exist.c
+++ b/clang/test/Profile/profile-does-not-exist.c
@@ -1,4 +1,4 @@
 // RUN: not %clang_cc1 -emit-llvm %s -o - -fprofile-instrument-use-path=%t.nonexistent.profdata 2>&1 | FileCheck %s
 
-// CHECK: error: Could not read profile {{.*}}.nonexistent.profdata:
+// CHECK: error: Error in reading profile {{.*}}.nonexistent.profdata:
 // CHECK-NOT: Assertion failed