diff --git a/compiler-rt/lib/profile/InstrProfilingFile.c b/compiler-rt/lib/profile/InstrProfilingFile.c
--- a/compiler-rt/lib/profile/InstrProfilingFile.c
+++ b/compiler-rt/lib/profile/InstrProfilingFile.c
@@ -993,6 +993,12 @@
  */
 COMPILER_RT_VISIBILITY
 void __llvm_profile_initialize(void) {
+  const uint64_t NumCounters = __llvm_profile_get_num_counters(
+      __llvm_profile_begin_counters(), __llvm_profile_end_counters());
+  // If there are no counters, do not initialize profile runtime.
+  if (!NumCounters)
+    return;
+
   __llvm_profile_initialize_file();
   if (!__llvm_profile_is_continuous_mode_enabled())
     __llvm_profile_register_write_file_atexit();
diff --git a/compiler-rt/test/profile/Linux/instrprof-profile-filter-no-profile.c b/compiler-rt/test/profile/Linux/instrprof-profile-filter-no-profile.c
new file mode 100644
--- /dev/null
+++ b/compiler-rt/test/profile/Linux/instrprof-profile-filter-no-profile.c
@@ -0,0 +1,8 @@
+// Test that no profile is generated when a src file is not in the
+//    selected files list provided via -fprofile-list.
+// RUN: echo "src:other.c" | sed -e 's/\\/\\\\/g' > %t-file.list
+// RUN: %clang_profgen -fprofile-list=%t-file.list -o %t %s
+// RUN: env LLVM_PROFILE_FILE=%t.profraw %run %t
+// RUN: not test -f %t.profraw
+
+int main() { return 0; }