diff --git a/openmp/libomptarget/include/device.h b/openmp/libomptarget/include/device.h
--- a/openmp/libomptarget/include/device.h
+++ b/openmp/libomptarget/include/device.h
@@ -508,4 +508,10 @@
 
 extern PluginManager *PM;
 
+/// Allocate memory and initialize the plugin manager.
+void initLibomptarget();
+
+/// Deallocate the plugin manager.
+void deinitLibomptarget();
+
 #endif
diff --git a/openmp/libomptarget/src/interface.cpp b/openmp/libomptarget/src/interface.cpp
--- a/openmp/libomptarget/src/interface.cpp
+++ b/openmp/libomptarget/src/interface.cpp
@@ -21,10 +21,18 @@
 #include <cstdlib>
 #include <mutex>
 
+// The number of libraries that have been registered by the user.
+static std::atomic<uint32_t> LibraryUsers;
+
 ////////////////////////////////////////////////////////////////////////////////
 /// adds requires flags
 EXTERN void __tgt_register_requires(int64_t Flags) {
   TIMESCOPE();
+
+  // Make sure that someone has initialized Libomptarget first.
+  if (!PM)
+    initLibomptarget();
+
   PM->RTLs.registerRequires(Flags);
 }
 
@@ -32,6 +40,12 @@
 /// adds a target shared library to the target execution image
 EXTERN void __tgt_register_lib(__tgt_bin_desc *Desc) {
   TIMESCOPE();
+
+  // Before we load any libraries we need to make sure that Libomptarget has
+  // been initialized.
+  if (!PM)
+    initLibomptarget();
+
   std::call_once(PM->RTLs.InitFlag, &RTLsTy::loadRTLs, &PM->RTLs);
   for (auto &RTL : PM->RTLs.AllRTLs) {
     if (RTL.register_lib) {
@@ -41,6 +55,8 @@
     }
   }
   PM->RTLs.registerLib(Desc);
+
+  LibraryUsers++;
 }
 
 ////////////////////////////////////////////////////////////////////////////////
@@ -59,6 +75,10 @@
       }
     }
   }
+
+  // Uninitialize libomptarget once all the libraries have been unloaded.
+  if (!--LibraryUsers)
+    deinitLibomptarget();
 }
 
 /// creates host-to-target data mapping, stores it in the
diff --git a/openmp/libomptarget/src/omptarget.cpp b/openmp/libomptarget/src/omptarget.cpp
--- a/openmp/libomptarget/src/omptarget.cpp
+++ b/openmp/libomptarget/src/omptarget.cpp
@@ -268,9 +268,9 @@
 }
 
 static bool isOffloadDisabled() {
-  if (PM->TargetOffloadPolicy == tgt_default)
+  if (PM && PM->TargetOffloadPolicy == tgt_default)
     handleDefaultTargetOffload();
-  return PM->TargetOffloadPolicy == tgt_disabled;
+  return !PM || PM->TargetOffloadPolicy == tgt_disabled;
 }
 
 // If offload is enabled, ensure that device DeviceID has been initialized,
diff --git a/openmp/libomptarget/src/rtl.cpp b/openmp/libomptarget/src/rtl.cpp
--- a/openmp/libomptarget/src/rtl.cpp
+++ b/openmp/libomptarget/src/rtl.cpp
@@ -17,6 +17,7 @@
 #include "llvm/Object/OffloadBinary.h"
 
 #include <cassert>
+#include <condition_variable>
 #include <cstdlib>
 #include <cstring>
 #include <dlfcn.h>
@@ -34,13 +35,21 @@
     /* Remote target        */ "libomptarget.rtl.rpc.so",
 };
 
-PluginManager *PM;
+PluginManager *PM = nullptr;
+static std::mutex PluginMutex;
 
 #if OMPTARGET_PROFILE_ENABLED
 static char *ProfileTraceFile = nullptr;
 #endif
 
-__attribute__((constructor(101))) void init() {
+void initLibomptarget() {
+  PluginMutex.lock();
+
+  if (PM) {
+    PluginMutex.unlock();
+    return;
+  }
+
   DP("Init target library!\n");
 
   bool UseEventsForAtomicTransfers = true;
@@ -63,9 +72,10 @@
   if (ProfileTraceFile)
     llvm::timeTraceProfilerInitialize(500 /* us */, "libomptarget");
 #endif
+  PluginMutex.unlock();
 }
 
-__attribute__((destructor(101))) void deinit() {
+void deinitLibomptarget() {
   DP("Deinit target library!\n");
 
   for (auto *R : PM->RTLs.UsedRTLs) {